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Grantee Research Project Results

Journal Publications Details for Grant Number R825384

Health Risk of the Trihalomethanes Found in Drinking Water Carcinogenic Activity and Interactions

RFA: Drinking Water (1996)

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Journal Article (7)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Journal Article Effect of trihalomethanes on cell proliferation and DNA methylation in female B6C3F1 mouse liver. TOXICOLOGICAL SCIENCES Coffin JC, Ge R, Yang S, Kramer PM, Tao L, Pereira MA Coffin JC, Ge R, Yang S, Kramer PM, Tao L, Pereira MA. Effect of trihalomethanes on cell proliferation and DNA methylation in female B6C3F1 mouse liver. Toxicological Sciences 2000;58(2):243-252. R825384 (Final)
  • Abstract from PubMed
  • Full-text: Toxicological Sciences
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  • Other: Toxicological Sciences PDF
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Journal Article The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice None Ge R, Yang S, Kramer PM, Tao L, Pereira MA. Ge R, Yang S, Kramer PM, Tao L, Pereira MA. The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice. Journal of Biochemical and Molecular Toxicology 2001;15(2):100-106. R825384 (Final)
  • Abstract from PubMed
Journal Article Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. None Pereira MA, Kramer PM, Conran PB, Tao L Pereira MA, Kramer PM, Conran PB, Tao L. Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. Carcinogenesis 2001;22(9):1511-1519. R825384 (Final)
R828083 (2000)
R828083 (2001)
R828083 (Final)
  • Abstract from PubMed
  • Full-text: Carcinogenesis
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  • Other: Carcinogenesis
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Journal Article Effect of dichloroacetic acid and trichloroacetic acid on DNA methylation in liver and tumors of female B6C3F1 mice. TOXICOLOGICAL SCIENCES Tao LH, Kramer PM, Ge RG, Pereira MA Tao L, Kramer PM, Ge R, Pereira MA. Effect of dichloroacetic acid and trichloroacetic acid on DNA methylation in liver and tumors of female B6C3F1 mice. Toxicological Sciences 1998;43(2):139-144. R825384 (Final)
  • Abstract from PubMed
  • Full-text: Toxicological Sciences PDF
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Journal Article Effect of trichloroethylene on DNA methylation and expression of early-intermediate protooncogenes in the liver of B6C3F1 mice. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Tao LH, Ge RR, Xie M, Kramer PM, Pereira MA Tao L, Ge R, Xie M, Kramer PM, Pereira MA. Effect of trichloroethylene on DNA methylation and expression of early-intermediate protooncogenes in the liver of B6C3F1 mice. Journal of Biochemical and Molecular Toxicology 1999;13(5):231-237. R825384 (Final)
  • Abstract from PubMed
  • Full-text: Wiley - Full Text HTML
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  • Abstract: Wiley - Abstract HTML
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Journal Article Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine. TOXICOLOGICAL SCIENCES Tao LH, Yang SM, Xie M, Kramer PM, Pereira MA Tao L, Yang S, Xie M, Kramer PM, Pereira MA. Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver:prevention by methionine. Toxicological Sciences 2000;54(2):399-407. R825384 (Final)
  • Abstract from PubMed
  • Full-text: Toxicological Sciences
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  • Other: Toxicological Sciences PDF
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Journal Article Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. CANCER LETTERS Tao LH, Yang SM, Xie M, Kramer PM, Pereira MA Tao L, Yang S, Xie M, Kramer PM, Pereira MA. Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Cancer Letters 2000;158(2):185-193. R825384 (Final)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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