Grantee Research Project Results
Journal Publications for Center:
Disparities in Exposure and Health Effects of Multiple Environmental Stressors Across the Life Course
Grant Number R836156
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Development and evaluation of a new compact mechanism for aromatic oxidation in atmospheric models | ATMOSPHERIC CHEMISTRY AND PHYSICS | Bates K, Jacob D, Li K, Ivatt P, Evans M, Yan Y, Lin J | Bates K, Jacob D, Li K, Ivatt P, Evans M, Yan Y, Lin J. Development and evaluation of a new compact mechanism for aromatic oxidation in atmospheric models. Atmospheric Chemistry and Physics 2021;21(24):18351-18374. |
R840014 (2021) R840014 (2023) |
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Journal Article | Stage-dependent accumulation of cadmium and induction of metallothionein-like binding activity in the testis of the dogfish shark, Squalus acanthias. | BIOLOGY OF REPRODUCTION | Betka M, Callard GV | Betka M, Callard GV. Stage-dependent accumulation of cadmium and induction of metallothionein-like binding activity in the testis of the dogfish shark, Squalus acanthias. Biology of Reproduction 1999;60(1):14-22. |
R825434 (Final) |
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Journal Article | Characterization of two aryl hydrocarbon receptor (AHR) mRNA forms in Squalus acanthias and stage-dependent expression during spermatogenesis. | None | Betka M, Welenc A, Franks DG, Hahn ME, Callard GV | Betka M, Welenc A, Franks DG, Hahn ME, Callard GV. Characterization of two aryl hydrocarbon receptor (AHR) mRNA forms in Squalus acanthias and stage-dependent expression during spermatogenesis. The Bulletin, Mount Desert Island Biological Laboratory 2000;39:110-112. |
R825434 (Final) |
not available |
Journal Article | Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART D: GENOMICS AND PROTEOMICS | Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Oleksiak MF, Rees BB, Singer TD, Stegeman JJ, Towle DW, Van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL | Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Oleksiak MF, Rees BB, Singer TD, Stegeman JJ, Towle DW, Van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2007;2(4):257-286. |
R831301 (Final) |
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Journal Article | The role of non-chemical stressors in mediating socioeconomic susceptibility to environmental chemicals. | CURRENT ENVIRONMENTAL HEALTH REPORTS | Clougherty JE, Shmool JLC, Kubzansky LD | Clougherty JE, Shmool JLC, Kubzansky LD. The role of non-chemical stressors in mediating socioeconomic susceptibility to environmental chemicals. Current Environmental Health Reports 2014;1(4):302-313. |
R834576 (2013) R834576 (2014) R834576 (Final) |
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Journal Article | Background nitrogen dioxide (NO2) over the United States and itsimplications for satellite observations and trends: effects of nitratephotolysis, aircraft, and open fires | ATMOSTPHERIC CHEMISTRY AND PHYSICS | Gang R, Jacob D, Shah V, Eastham S, Fritz T, Mickley L, Liu T, Wang Y, Wang J | Gang R, Jacob D, Shah V, Eastham S, Fritz T, Mickley L, Liu T, Wang Y, Wang J. Background nitrogen dioxide (NO2) over the United States and itsimplications for satellite observations and trends: effects of nitratephotolysis, aircraft, and open fires. ATMOSTPHERIC CHEMISTRY AND PHYSICS 2023;23(11):6271-6284 |
R840014 (2022) |
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Journal Article | Isolation and characterization of two cytochrome P450 aromatase forms in killifish (Fundulus heteroclitus): differential expression in fish from polluted and unpolluted environments. | AQUATIC TOXICOLOGY | Greytak SR, Champlin D, Callard GV | Greytak SR, Champlin D, Callard GV. Isolation and characterization of two cytochrome P450 aromatase forms in killifish (Fundulus heteroclitus): differential expression in fish from polluted and unpolluted environments. Aquatic Toxicology 2005;71(4):371-389. |
R831301 (2006) R831301 (Final) |
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Journal Article | Cloning of three estrogen receptors (ER) from killifish (Fundulus heteroclitus): differences in populations from polluted and reference environments. | GENERAL AND COMPARATIVE ENDOCRINOLOGY | Greytak SR, Callard GV | Greytak SR, Callard GV. Cloning of three estrogen receptors (ER) from killifish (Fundulus heteroclitus): differences in populations from polluted and reference environments. General and Comparative Endocrinology 2007;150(1):174-188. |
R831301 (2006) R831301 (Final) |
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Journal Article | Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site-and gene-specific | AQUATIC TOXICOLOGY | Greytak SR, Tarrant A, Hahn M, Callard GV | Greytak SR, Tarrant AM, Nacci D, Hahn ME, Callard GV. Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site-and gene-specific. Aquatic Toxicology 2010;99(2):291-299. |
R831301 (Final) |
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Journal Article | An Online-Learned Neural Network Chemical Solver for Stable Long-Term Global Simulations of Atmospheric Chemistry | JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS | Kelp M, Jacob D, Lin H, Sulprizio M | Kelp M, Jacob D, Lin H, Sulprizio M. An online-learned neural network chemical solver for stable long-term gobal simulations of atmospheric chemistry. Journal of Advances in Modeling Earth Systems 2022;14(6). |
R840014 (2021) R840014 (2023) |
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Journal Article | Community-wide health risk assessment using geographically resolved demographic data: a synthetic population approach. | None | Levy JI, Fabian MP, Peters JL | Levy JI, Fabian MP, Peters JL. Community-wide health risk assessment using geographically resolved demographic data: a synthetic population approach. PLoS One 2014;9(1):e87144 (10 pp.). |
R834577 (Final) |
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Journal Article | Meta-analytic approaches for multistressor dose-response function development: strengths, limitations, and case studies. | None | Levy JI, Fabian MP, Peters JL | Levy JI, Fabian MP, Peters JL. Meta-analytic approaches for multistressor dose-response function development: strengths, limitations, and case studies. Risk Analysis 2015;35(6):1040-1049. |
R834557 (Final) R834577 (Final) R834798 (Final) |
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Journal Article | Stage and season effects on cell cycle and apoptotic activities of germ cells and Sertoli cells during spermatogenesis in the spiny dogfish (Squalus acanthias). | REPRODUCTION | McClusky LM | McClusky LM. Stage and season effects on cell cycle and apoptotic activities of germ cells and Sertoli cells during spermatogenesis in the spiny dogfish (Squalus acanthias). Reproduction 2005;129(1):89-102. |
R825434 (Final) |
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Journal Article | Stage-dependency of apoptosis and the blood-testis barrier in the dogfish shark (Squalus acanthias): cadmium-induced changes as assessed by vital fluorescence techniques. | CELL AND TISSUE RESEARCH | McClusky LM | McClusky LM. Stage-dependency of apoptosis and the blood-testis barrier in the dogfish shark (Squalus acanthias): cadmium-induced changes as assessed by vital fluorescence techniques. Cell and Tissue Research 2006;325(3):541-553. |
R825434 (Final) |
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Journal Article | Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment | BMC MOLECULAR BIOLOGY | McCurley A, Callard GV | McCurley AT, Callard GV. Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment. BMC Molecular Biology 2008;9:102. |
R831301 (Final) |
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Journal Article | A walk in the park: the influence of urban parks and community violence on physical activity in Chelsea, MA. | None | Ou JY, Levy JI, Peters JL, Bongiovanni R, Garcia-Soto J, Medina R, Scammell MK | Ou JY, Levy JI, Peters JL, Bongiovanni R, Garcia-Soto J, Medina R, Scammell MK. A walk in the park: the influence of urban parks and community violence on physical activity in Chelsea, MA. International Journal of Environmental Research and Public Health 2016;13(1):E97 (12 pp.). |
R834582 (Final) |
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Journal Article | Engaging communities in research on cumulative risk and social stress-environment interactions: lessons learned from EPA's STAR Program. | None | Payne-Sturges DC, Korfmacher KS, Cory-Slechta DA, Jimenez M, Symanski E, Carr Shmool JL, Dotson-Newman O, Cloughtery JE, French R, Levy JI, Laumbach R, Rodgers K, Bongiovanni R, Scammell MK | Payne-Sturges DC, Korfmacher KS, Cory-Slechta DA, Jimenez M, Symanski E, Carr Shmool JL, Dotson-Newman O, Cloughtery JE, French R, Levy JI, Laumbach R, Rodgers K, Bongiovanni R, Scammell MK. Engaging communities in research on cumulative risk and social stress-environment interactions: lessons learned from EPA's STAR Program. Environmental Justice 2015;8(6):203-212. |
R834576 (Final) R834577 (Final) R834578 (Final) R834579 (Final) R834580 (Final) R834581 (Final) R834582 (Final) |
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Journal Article | Combined impact of lead, cadmium, polychlorinated biphenyls and non-chemical risk factors on blood pressure in NHANES. | None | Peters JL, Fabian MP, Levy JI | Peters JL, Fabian MP, Levy JI. Combined impact of lead, cadmium, polychlorinated biphenyls and non-chemical risk factors on blood pressure in NHANES. Environmental Research 2014;132:93-99. |
R834577 (Final) |
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Journal Article | Is All Urban Green Space the Same? A Comparison of the Health Benefits of Trees and Grass in New York City | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | Reid C, Clougherty J, Schmool J, Kubzansky L | Reid C, Clougherty J, Schmool J, Kubzansky L. Is All Urban Green Space the Same? A Comparison of the Health Benefits of Trees and Grass in New York City. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2017;14(11):1411. |
R834576 (Final) |
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Journal Article | Real-time PCR analysis of cytochrome P450 aromatase expression in zebrafish: gene specific tissue distribution, sex differences, developmental programming, and estrogen regulation. | GENERAL AND COMPARATIVE ENDOCRINOLOGY | Sawyer SJ, Gerstner KA, Callard GV | Sawyer SJ, Gerstner KA, Callard GV. Real-time PCR analysis of cytochrome P450 aromatase expression in zebrafish: gene specific tissue distribution, sex differences, developmental programming, and estrogen regulation. General and Comparative Endocrinology 2006;147(2):108-117. |
R831301 (2004) R831301 (2006) R831301 (Final) |
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Journal Article | Tools for addressing cumulative impacts on human health and the environment. | None | Scammell MK, Montague P, Raffensperger C | Scammell MK, Montague P, Raffensperger C. Tools for addressing cumulative impacts on human health and the environment. Environmental Justice 2014;7(4):102-109. |
R834582 (Final) |
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Journal Article | Global modeling of cloud water acidity, precipitation acidity, and acid inputs to ecosystems. | ATMOSPHERIC CHEMISTRY AND PHYSICS | Shah V, Jacob DJ, Moch JM, Wang X, Zhai S | Shah V, Jacob DJ, Moch JM, Wang X, Zhai S. Global modeling of cloud water acidity, precipitation acidity, and acid inputs to ecosystems. Atmospheric Chemistry and Physics 2020;20:12223–45 |
R840014 (2023) |
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Journal Article | Social stressors and air pollution across New York City communities: a spatial approach for assessing correlations among multiple exposures. | ENVIRONMENTAL HEALTH | Shmool JL, Kubzansky LD, Newman OD, Spengler J, Shepard P, Clougherty JE | Shmool JLC, Kubzansky LD, Newman OD, Spengler J, Shepard P, Clougherty JE. Social stressors and air pollution across New York City communities: a spatial approach for assessing correlations among multiple exposures. Environmental Health 2014;13:91. |
R834576 (2012) R834576 (2013) R834576 (2014) R834576 (Final) |
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Journal Article | Identifying perceived neighborhood stressors across diverse communities in New York City. | AMERICAN JOURNAL OF COMMUNITY PSYCHOLOGY | Shmool JL, Yonas MA, Newman OD, Kubzansky LD, Joseph E, Parks A, Callaway C, Chubb LG, Shepard P, Clougherty JE | Shmool JL, Yonas MA, Newman OD, Kubzansky LD, Joseph E, Parks A, Callaway C, Chubb LG, Shepard P, Clougherty JE. Identifying perceived neighborhood stressors across diverse communities in New York City. American Journal of Community Psychology 2015;56(1-2):144-155. |
R834576 (2012) R834576 (2013) R834576 (2014) R834576 (Final) |
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Journal Article | Area-level socioeconomic deprivation, nitrogen dioxide exposure, and term birth weight in New York City. | ENVIRONMENTAL RESEARCH | Shmool JLC, Bobb JF, Ito K, Elston B, Savitz DA, Ross Z, Matte TD, Johnson S, Dominici F, Clougherty JE | Shmool JLC, Bobb JF, Ito K, Elston B, Savitz DA, Ross Z, Matte TD, Johnson S, Dominici F, Clougherty JE. Area-level socioeconomic deprivation, nitrogen dioxide exposure, and term birth weight in New York City. Environmental Research 2015;142:624-632. |
R834576 (Final) |
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Journal Article | Spatio-temporal ozone variation in a case-crossover analysis of childhood asthma hospital visits in New York City. | None | Shmool JLC, Kinnee E, Sheffield PE, Clougherty JE | Shmool JLC, Kinnee E, Sheffield PE, Clougherty JE. Spatio-temporal ozone variation in a case-crossover analysis of childhood asthma hospital visits in New York City. Environmental Research 2016;147:108-114. |
R834576 (Final) |
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Journal Article | On the reduction of basic iron acetate: Isolation of ferrous species mediating gif-type oxidation of hydrocarbons. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | Singh B, Long JR, Papaefthymiou GC, Stavropoulos P | Singh B, Long JR, Papaefthymiou GC, Stavropoulos P. On the reduction of basic iron acetate: Isolation of ferrous species mediating gif-type oxidation of hydrocarbons. Journal of the American Chemical Society 1996;118(24):5824-5825. |
R823377 (Final) |
not available |
Journal Article | Synthesis, reactivity, and catalytic behavior of iron/zinc-containing species involved in oxidation of hydrocarbons under Gif-type conditions. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | Singh B, Long JR, Fabrizi de Biani F, Gatteschi D, Stavropoulos P | Singh B, Long JR, Fabrizi de Biani F, Gatteschi D, Stavropoulos P. Synthesis, reactivity, and catalytic behavior of iron/zinc-containing species involved in oxidation of hydrocarbons under Gif-type conditions. Journal of the American Chemical Society 1997;119(30):7030-7047. |
R823377 (Final) |
not available |
Journal Article | Ligand-unsupported metal-metal (M=Cu, Ag) interactions between closed-shell d10 trinuclear systems. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | Singh K, Long JR, Stavropoulos P | Singh K, Long JR, Stavropoulos P. Ligand-unsupported metal-metal (M=Cu, Ag) interactions between closed-shell d10 trinuclear systems. Journal of the American Chemical Society 1997;119(12):2942-2943. |
R823377 (Final) |
not available |
Journal Article | Polynuclear complexes of copper(I) and the 2-(3(5)-pyrazolyl), 6-methylpyridine ligand: structures and reactivity toward small molecules. | INORGANIC CHEMISTRY | Singh K, Long JR, Stavropoulos J | Singh K, Long JR, Stavropoulos J. Polynuclear complexes of copper(I) and the 2-(3(5)-pyrazolyl), 6-methylpyridine ligand: structures and reactivity toward small molecules. Inorganic Chemistry 1998;37(5):1073-1079. |
R823377 (Final) |
not available |
Journal Article | Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. | JOURNAL OF MOLECULAR AND CELLULAR ENDOCRINOLOGY | Tarrant AM, Greytak SR, Callard GV, Hahn ME | Tarrant AM, Greytak SR, Callard GV, Hahn ME. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. Journal of Molecular and Cellular Endocrinology 2006;37(1):105-120. |
R831301 (2006) R831301 (Final) |
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Journal Article | Polymerase chain reaction (PCR)-differential display identifies a subset of stage-dependent and cadmium-regulated genes during spermatogenesis in Squalus acanthias. | None | Wang C, Callard GV | Wang C, Callard GV. Polymerase chain reaction (PCR)-differential display identifies a subset of stage-dependent and cadmium-regulated genes during spermatogenesis in Squalus acanthias. The Bulletin, Mount Desert Island Biological Laboratory 2001;40:96-98. |
R825434 (Final) |
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Journal Article | Toward stable, general machine-learned models of the atmospheric chemical system. | None | Kelp MM, Jacob DJ, Kutz JN, Marshall JD, Tessum CW | Kelp MM, Jacob DJ, Kutz JN, Marshall JD, Tessum CW. Toward stable, general machine-learned models of the atmospheric chemical system. Journal of Geophysical Research-Atmospheres 2020;125:e2020JD032759. |
R835873 (2020) R835873 (Final) R840012 (2021) R840012 (2022) R840012 (2023) R840014 (2023) |
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Journal Article | Improved mechanistic model of the atmospheric redox chemistry of mercury. | ENVIRONMENTAL SCIENCE & TECHNOLOGY | Shah V, Jacob DJ, Thackray CP, Wang X, Sunderland EM, Dibble TS, Saiz-Lopez A, Černušák I, Kellö V, Castro PJ, Wu R, Wang C | Shah V, Jacob DJ, Thackray CP, Wang X, Sunderland EM, Dibble TS, Saiz-Lopez A, Černušák I, Kellö V, Castro PJ, Wu R, Wang C. Improved mechanistic model of the atmospheric redox chemistry of mercury. Environmental Science & Technology 2021. |
R840014 (2023) |
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Journal Article | The global budget of atmospheric methanol: New constraints on secondary, oceanic, and terrestrial Sources. | JOURNAL OF GEOPHYSICAL RESESEARCH-ATMOSPHERE | Bates KH, Jacob DJ, Wang S, Hornbrook RS, Apel EC, Kim MJ, Millet DB, Wells KC, Chen X, Brewer JF, Ray EA, Commane R, Diskin GS, Wofsy SC | Bates KH, Jacob DJ, Wang S, Hornbrook RS, Apel EC, Kim MJ, Millet DB, Wells KC, Chen X, Brewer JF, Ray EA, Commane R, Diskin GS, Wofsy SC. The global budget of atmospheric methanol: New constraints on secondary, oceanic, and terrestrial Sources. Journal of Geophysical Research-Atmosphere 2021;126:e2020JD033439. |
R840014 (2023) |
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Journal Article | Global tropospheric halogen (Cl, Br, I) chemistry and its impact on oxidants. | ATMOSPHERIC CHEMISTRY AND PHYSICS | Wang X, Jacob DJ, Downs W, Zhai S, Zhu L, Shah V, Holmes CD, Sherwen T, Alexander B, Evans MJ, Eastham SD, Neuman JA, Veres P, Koenig TK, Volkamer R, Huey LG, et al | Wang X, Jacob DJ, Downs W, Zhai S, Zhu L, Shah V, Holmes CD, Sherwen T, Alexander B, Evans MJ, Eastham SD, Neuman JA, Veres P, Koenig TK, Volkamer R, Huey LG, et al. Global tropospheric halogen (Cl, Br, I) chemistry and its impact on oxidants. Atmospheric Chemistry and Physics 2021:1–34 |
R840014 (2023) |
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Journal Article | Background nitrogen dioxide (NO2) over the United States and its implications for satellite observations and trends:effects of nitrate photolysis, aircraft, and open fires. | None | Dang R, Jacob DJ, Shah V, Eastham SD, Fritz TM, Mickley LJ, Liu T, Wang Y, Wang J | Dang R, Jacob DJ, Shah V, Eastham SD, Fritz TM, Mickley LJ, Liu T, Wang Y, Wang J. Background nitrogen dioxide (NO2) over the United States and its implications for satellite observations and trends:effects of nitrate photolysis, aircraft, and open fires. Atmospheric Chemistry and Physics 2023;23:6271–84. doi:10.5194/acp-23-6271-2023. |
R840014 (2023) |
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Journal Article | An adaptive auto-reduction solver for speeding up integration of chemical kinetics in atmospheric chemistry models:Implementation and evaluation in the Kinetic Pre-Processor (KPP) Version 3. | JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS | Lin H, Long MS, Sander R, Sandu A, Yantosca RM, Estrada LA, Shen L, Jacob DJ | Lin H, Long MS, Sander R, Sandu A, Yantosca RM, Estrada LA, Shen L, Jacob DJ. An adaptive auto-reduction solver for speeding up integration of chemical kinetics in atmospheric chemistry models:Implementation and evaluation in the Kinetic Pre-Processor (KPP) Version 3.0.0. Journal of Advances in Modeling Earth Systems 2023;15:e2022MS003293. doi:10.1029/2022MS003293. |
R840014 (2023) |
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Journal Article | Nitrogen oxides in the free troposphere: Implications for tropospheric oxidants and the interpretation of satellite NO2 measurements. | ATMOSPHERIC CHEMISTRY AND PHYSICS | Shah V, Jacob DJ, Dang R, Lamsal LN, Strode SA, Steenrod SD, Boersma KF, Eastham SD, Fritz TM, Thompson C, Peischl J, Bourgeois I, Pollack IB, Nault BA, Cohen RC, Campuzano-Jost P, et al | Shah V, Jacob DJ, Dang R, Lamsal LN, Strode SA, Steenrod SD, Boersma KF, Eastham SD, Fritz TM, Thompson C, Peischl J, Bourgeois I, Pollack IB, Nault BA, Cohen RC, Campuzano-Jost P, et al. Nitrogen oxides in the free troposphere: Implications for tropospheric oxidants and the interpretation of satellite NO2 measurements. Atmospheric Chemistry and Physics 2023;23:1227–57. doi:10.5194/acp-23-1227-2023. |
R840014 (2023) |
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Journal Article | A machine-learning-guided adaptive algorithm to reduce the computational cost of integrating kinetics in global atmospheric chemistry models:Application to GEOS-Chem versions 12. | None | Shen L, Jacob DJ, Santillana M, Bates K, Zhuang J, Chen W | Shen L, Jacob DJ, Santillana M, Bates K, Zhuang J, Chen W. A machine-learning-guided adaptive algorithm to reduce the computational cost of integrating kinetics in global atmospheric chemistry models:Application to GEOS-Chem versions 12.0.0 and 12.9.1. Geoscientific Model Development 2022;15:1677–87. doi:10.5194/gmd-15-1677-2022. |
R840014 (2023) |
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Journal Article | Impacts of updated reaction kinetics on the global GEOS-Chem simulation of atmospheric chemistry | None | Bates K, Evans M, Henderson B, and Jacob D | Bates K, Evans M, Henderson B, and Jacob D. Impacts of updated reaction kinetics on the global GEOS-Chem simulation of atmospheric chemistry. EGUsphere [preprint] 2023; https://doi.org/10.5194/egusphere-2023-1374. |
R840014 (2023) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.