Grantee Research Project Results
2010 Progress Report: Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development
EPA Grant Number: R834593Center: Water Innovation Network for Sustainable Small Systems
Center Director: Reckhow, David A.
Title: Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development
Investigators: Schantz, Susan L. , Korrick, Susan A. , Baillargeon, Renee L. , Aguiar, Andrea , Juraska, Janice , Flaws, Jodi , Gardnier, Joseph
Current Investigators: Schantz, Susan L. , Korrick, Susan A. , Juraska, Janice , Flaws, Jodi
Institution: University of Illinois Urbana-Champaign , Harvard University , Michigan State University
Current Institution: University of Illinois Urbana-Champaign , Harvard University
EPA Project Officer: Hahn, Intaek
Project Period: February 15, 2010 through February 14, 2014
Project Period Covered by this Report: February 15, 2010 through February 14,2011
Project Amount: $1,094,951
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Progress Summary:
Progress and Key Findings: In the perinatal exposure groups, maternal behavior was monitored for the first 15 postnatal days. Some doses of BPA were found to increase maternal licking over controls. The group exposed to 40 µg/kg/day had more significantly more licking than controls, and the 4 µg/kg/day group also showed a trend toward more licking. The group exposed to 400 µg/kg/day did not exhibit more licking. No other behavioral category was affected by BPA in these dams. In some dose groups, the weights of perinatally BPA-exposed rats were increased both at weaning and in young adulthood, especially in females. Cognitive data from the perinatally BPA-exposed groups are currently undergoing statistical analysis, and brains have been harvested cut and stained for cell counting. The adolescent exposure studies are also underway.
Journal Articles: 9 Displayed | Download in RIS Format
Other center views: | All 35 publications | 9 publications in selected types | All 9 journal articles |
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Brannick KE, Craig ZR, Himes AD, Peretz JR, Wang W, Flaws JA, Raetzman LT. Prenatal exposure to low doses of bisphenol A increases pituitary proliferation and gonadotroph number in female mice offspring at birth. Biology of Reproduction 2012;87(4):82 (10 pp.). |
R834593 (2012) R834593C001 (Final) R834593C003 (2012) |
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Minihagalle S, You T, Suh L, Patel C, Gao L, Rattan S, Qiao H. Prenatal exposure to di-(2-ethylhexyl) phthalate and high-fat diet synergistically disrupts mouse fetal oogenesis and affects folliculogenesis. BIOLOGY OF REPRODUCTION 2019;100(6):1561-1570. |
R834593 (Final) |
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Peretz J, Gupta RK, Singh J, Hernandez-Ochoa I, Flaws JA. Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway. Toxicological Sciences 2011;119(1):209-217. |
R834593 (2012) R834593C001 (Final) R834593C003 (2012) |
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Peretz J, Craig ZR, Flaws JA. Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway. Biology of Reproduction 2012;87(3):63 (11 pp.). |
R834593 (2012) R834593C001 (Final) R834593C003 (2012) |
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Peretz J, Flaws JA. Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles. Toxicology and Applied Pharmacology 2013;271(2):249-256. |
R834593C001 (Final) |
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Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. Bisphenol A and reproductive health: update of experimental and human evidence, 2007-2013. Environmental Health Perspectives 2014;122(8):775-786. |
R834593C001 (Final) R835434 (2013) R835434 (2014) R835436 (2014) R835436 (2015) R835436 (2017) |
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Sadowski RN, Park P, Neese SL, Ferguson DC, Schantz SL, Juraska JM. Effects of perinatal bisphenol A exposure during early development on radial arm maze behavior in adult male and female rats. Neurotoxicology and Teratology 2014;42:17-24. |
R834593C001 (Final) |
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Sadowski RN, Wise LM, Park PY, Schantz SL, Juraska JM. Early exposure to bisphenol A alters neuron and glia number in the rat prefrontal cortex of adult males, but not females. Neuroscience 2014;279:122-131. |
R834593C001 (Final) |
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Shoaff JR, Calafat AM, Schantz, SL, Korrick SA. Endocrine Disrupting Chemical Exposure and Maladaptive Behavior during Adolescence. Environmental Research 2019;172:231-241. |
R834593 (Final) |
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Supplemental Keywords:
Health effects, sensitive populations, genetic polymorphisms, epidemiologyProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834593C001 Prenatal Exposure to BPA/Phthalates: Infant Physical and Behavioral Development
R834593C002 Adolescent Exposure to BPA/Phthalates Cognitive and Behavioral Development
R834593C003 Mechanisms of In Utero BPA Exposure on Fetal Gonad Development
R834593C004 Effects of Bisphenol A on the Developing Cortex
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.