Grantee Research Project Results
Dendritic Cell Activation by Particulate Matter and Allergen
EPA Grant Number: R832139C004Subproject: this is subproject number 004 , established and managed by the Center Director under grant R832139
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Dendritic Cell Activation by Particulate Matter and Allergen
Investigators: Georas, Steven
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The overall goal of the research project is to examine the influence of airborne particulates and bioaerosols on airway immune responses associated with asthma. The specific objectives are to: (1) test the hypothesis that particulate matter (PM) influences dendritic cell (DC) maturation; and (2) test the hypothesis that PM interacts with allergen to induce a Th2-promoting DC phenotype.
Publications and Presentations:
Publications have been submitted on this subproject: View all 7 publications for this subproject | View all 117 publications for this centerJournal Articles:
Journal Articles have been submitted on this subproject: View all 7 journal articles for this subproject | View all 113 journal articles for this centerSupplemental Keywords:
airborne particulates, asthma, dendritic cells, allergens, particulate matter, PM, children’s health,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, HUMAN HEALTH, particulate matter, Genetics, Health Risk Assessment, Allergens/Asthma, Health Effects, Physical Processes, asthma, children's health, asthma triggers, air toxics, exposure, air pollution, children, bioaerosols, air pollutant, human exposure, airborne pollutants, PM, allergensProgress and Final Reports:
Main Center Abstract and Reports:
R832139 Center for the Study of Childhood Asthma in the Urban Environment Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832139C001 The Epidemiology of Susceptibility to Airborne Particulates and Allergens to Asthma in African Americans
R832139C002 A Randomized Controlled Trial of Behavior Changes in Home Exposure Control
R832139C003 Mechanisms of Particulate-Induced Allergic Asthma
R832139C004 Dendritic Cell Activation by Particulate Matter and Allergen
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2009
- 2008
- 2007 Progress Report
- 2006 Progress Report
- 2005 Progress Report
- 2004 Progress Report
7 journal articles for this subproject
Main Center: R832139
117 publications for this center
113 journal articles for this center