Grantee Research Project Results
Role of Interindividual Variation in Human Susceptibility to Cancer Toxicological Implications of a Polymorphism in NQO1
EPA Grant Number: R825281Title: Role of Interindividual Variation in Human Susceptibility to Cancer Toxicological Implications of a Polymorphism in NQO1
Investigators: Ross, David
Institution: University of Colorado Health Sciences Center
EPA Project Officer: Aja, Hayley
Project Period: December 15, 1996 through December 14, 1999
Project Amount: $531,787
RFA: Role of Interindividual Variation in Human Susceptibility to Cancer (1996) RFA Text | Recipients Lists
Research Category: Human Health
Description:
NAD(P)H:Quinone oxidoreductase (NQO1, DT-diaphorase, EC 1.6.99.2) is an important enzyme with respect to the detoxification of xenobiotics and has been proposed to be important in both chemoprotection and chemoprevention. A polymorphism in NQO1 has recently been characterized which results in an absence of NQO1 protein and activity. The focus of this study will be to examine whether the polymorphism has any relevance for chemoprotection and chemoprevention. The prevalence of the NQO1 polymorphism will be characterized in different ethnic groups. Whether this polymorphism is associated with an increased incidence of benzene-induced DNA damage and hematotoxicity in occupationally-exposed workers will also be examined. A role for NQO1 in protection against cancer has been proposed and whether there is an increased prevalence of the NQO1 polymorphism in individuals who are genetically predisposed to colorectal cancer will be determined. The proposed studies should define the role of NQO1 in protection from benzene-induced toxicity and characterize the role of NQO1 in genetic predisposition to colorectal cancer.
Supplemental Keywords:
genetics, polymorphism, cancer, susceptibility, molecular epidemiology, human, gender, ethnic group, benzene, quinones., Health, RFA, Scientific Discipline, Toxics, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, genetic susceptability, HAPS, 33/50, Disease & Cumulative Effects, Genetics, Benzene (including benzene from gasoline), health effects, xenobiotics, genetic predisposition, health risks, harmful environmental agents, benzene, benzene exposure, human exposure, carcinogenesis, genetic polymorphisms, susceptibility, cancer risks, polymorphism, molecular epidemiology, xenobiotic metabolism, chemoprotection, colorectal cancer, exposure assessment, DNA damage, ethnic, genetic diversity, interindividual variabilityProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.