Asthma Indices Associated with Ambient Submicron Particles and Formaldehyde in Ambient Air Pollution

EPA Grant Number: R825275
Title: Asthma Indices Associated with Ambient Submicron Particles and Formaldehyde in Ambient Air Pollution
Institution: National Jewish Medical and Research Center
EPA Project Officer: Chung, Serena
Project Period: December 1, 1996 through November 30, 1997
Project Amount: $178,865
RFA: Air Quality (1996) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Air


Recent epidemiological studies have found an association between particulate air pollution and cardiopulmonary health effects, including increased asthma symptoms. There have been anecdotal reports of increased asthma symptoms associated with the use of oxygenated fuels, which are associated with increased emissions of aldehydes by motor vehicles. However, the biological mechanisms underlying these reported health effects are unknown. The purpose of this study is to test the hypotheses that indices of asthma are associated with ambient submicron particle counts and with ambient formaldehyde concentrations. This will be a prospective time-series study of the association between daily air pollutant concentrations and and daily symptom scores, medication use, and changes in lung function in a cohort of 60 young adults in downtown Denver, Colorado. The association between changes in asthma indices and baseline bronchial hyper-responsiveness will also be determined. The results will help determine the size fraction of particles which are most highly associated with changes of asthma indices, and may support an osmotic mechanism to explain worsening of asthma associated with particulate air pollution. Similarly, the results will help to clarify whether ambient aldehyde concentrations are associated with worsening of asthma.

Publications and Presentations:

Publications have been submitted on this project: View all 2 publications for this project

Supplemental Keywords:

air, ambient air, atmosphere, ozone, tropospheric, effects, health effects, sensitive populations, particulates, oxidants, epidemiology, Central, Colorado, CO, Region 8., RFA, Health, Scientific Discipline, Air, Geographic Area, particulate matter, air toxics, Epidemiology, State, Risk Assessments, mobile sources, Allergens/Asthma, tropospheric ozone, Atmospheric Sciences, EPA Region, ambient air quality, particle size, particulates, urban air, lungs, exposure and effects, cardiopulmonary responses, human health effects, motor vehicle emissions, air quality models, asthma indices, cardiovascular vulnerability, exposure, ambient air, air pollution, airway inflammation, oxidants, human exposure, Region 8, atmospheric transport, cardiopulmonary mechanisms, chronic health effects, lung inflammation, airborne pollutants, inhalation, Acute health effects, coronary artery disease, inhaled, aldehyde emissions, cardiotoxicity, Colorado (CO), aerosols, atmospheric chemistry, respiratory

Progress and Final Reports:

  • Final Report