Grantee Research Project Results
2006 Progress Report: Chronic Exposure to Particulate Matter and Cardiopulmonary Disease
EPA Grant Number: R830545Title: Chronic Exposure to Particulate Matter and Cardiopulmonary Disease
Investigators: Laden, Francine , Speizer, Frank E. , Suh, Helen H. , Neas, Lucas M. , Camargo, Carlos , Schwartz, Joel
Current Investigators: Laden, Francine , Schwartz, Joel , Speizer, Frank E. , Suh, Helen H. , Camargo, Carlos , Puett, Robin C. , Yanosky, Jeff D.
Institution: Brigham and Women’s Hospital , U. S. Environmental Protection Agency
Current Institution: Brigham and Women’s Hospital
EPA Project Officer: Chung, Serena
Project Period: January 20, 2003 through January 19, 2006 (Extended to January 19, 2008)
Project Period Covered by this Report: January 20, 2006 through January 19,2007
Project Amount: $933,602
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2002) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Human Health , Particulate Matter , Air
Objective:
We proposed: (1) to develop a model estimating long-term exposure to air pollution in the continental United States using existing databases, including the U.S. Environmental Protection Agency (EPA) Air Quality System (AQS); and (2) to evaluate the association of chronic exposure to air pollution with incident coronary and respiratory disease and total mortality in the Nurses’ Health Study (NHS), an ongoing prospective cohort study of 121,700 women residing throughout the United States. We hypothesize that the incidence of these diseases and total mortality are positively associated with air pollution and that exposure to air pollution exacerbates existing disease. We also hypothesize that the association with coronary heart disease will be greater among diabetics than nondiabetics and that consumption of antioxidants will modify the association.Approach:
The basic approach is threefold: (1) to use existing data sources to create a model for exposure to air pollution throughout the U.S.; (2) to link the yearly average exposure to the residential addresses of the study participants; and (3) to evaluate the relative risk of the outcomes in the high compared with the low exposure areas. We will model long-term exposure to air pollution for the years 1986 through 2000 using data from the EPA's Aerometric Information Retrieval System (AIRS), the National Emissions Trends database, National Oceanic and Atmospheric Association, and commercially available traffic count data. Existing ambient monitoring data from specific sites will be used to supplement this information. Residential addresses are updated every two years and will be mapped using geographic information system (GIS) software and linked to the exposure model. Incident cases of cardiovascular disease and of chronic obstructive pulmonary disease, asthma, and lung cancer, diagnosed during the study period, are identified routinely on the NHS biennial self-administered questionnaire. Cases are confirmed by supplemental questionnaire and review of medical records. Mortality is reported by next-of-kin and also obtained by regular searches of the National Death Index. We will estimate the relative risks of these outcomes associated with air pollution using the proportional hazards model, including adjustment for smoking, and other confounders. We will also assess interactions with comorbid diabetes and consumption of antioxidants.
Progress Summary:
We have developed a predictive model of particulate matter less than 10 microns in diameter (PM10) for the northeastern United States for the years 1988 through 2002. Finalization of a similar model for PM2.5 is currently underway. These models quantify chronic ambient exposure to air pollution in survival analyses of mortality and chronic disease outcomes in the Nurses’ Health Study. Follow-up questionnaires are mailed to participants every 2 years, thereby providing a complete residential address history. The 1988 through 2002 addresses have been geocoded and will provide a link to the prediction models.
Expected Results:
Although there is a substantial body of literature demonstrating the adverse health effects associated with air pollution, to date there have only been two large cohort studies of mortality. This proposed study will not only evaluate mortality but it will be the first study to prospectively evaluate cause-specific incident disease on a nationwide basis. Further, it will provide information on the extent of life shortening associated with the exposure by measuring survival and severity of disease after the first event.
Future Activities:
In the coming funding year, we will expand the PM10 model to the entire nation, and we will refine and expand the PM2.5 exposure model. In addition, we will refine our Cox proportional hazards models of the associations of chronic PM10 exposure with lung cancer, asthma, and chronic obstructive pulmonary disease. We will also use Cox proportional hazards models to examine the associations of chronic PM2.5 exposure with mortality and chronic health outcomes. Through this modeling process, we will examine potential confounders and effect modifiers, such as: smoking, physical activity, BMI, physician-diagnosed hypertension, and diabetes.Journal Articles:
No journal articles submitted with this report: View all 12 publications for this projectSupplemental Keywords:
epidemiology, health effects, ambient air, particulates, environmental monitoring, PM2.5, PM10, air pollutants, cardiovascular disease, chronic effects, chronic exposure, human exposure, mortality, exposure modeling, GIS, geocoding, asthma, chronic obstructive pulmonary disease, myocardial infarction, antioxidants, lung cancer, diabetes, smoking, physical activity, epidemiology, health effects, ambient air, particulates, susceptibility, diet,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, Ecosystem Protection/Environmental Exposure & Risk, HUMAN HEALTH, particulate matter, Bioavailability, Health Risk Assessment, air toxics, Exposure, Epidemiology, Monitoring/Modeling, Risk Assessments, Disease & Cumulative Effects, Environmental Monitoring, Physical Processes, tropospheric ozone, particulates, health effects, ambient air quality, sensitive populations, urban air, atmospheric measurements, EMPACT, chronic exposure, monitoring, PM 2.5, air pollutants, effects assessment, particulate, stratospheric ozone, acute cardiovascular effects, airway disease, pulmonary disease, ozone, continuous monitoring, ambient air, air pollution, children, carbon black, particles, human exposue, clinical studies, human exposure, chronic effects, sensitive subgroups, ecological risk, ambient particulates, Acute health effects, PM2.5, allergic response, cardiotoxicity, mortality, measurement methods , atmospheric chemistry, long-term exposure, cardiopulmonery responses, cardiovascular diseaseProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.