Grantee Research Project Results

Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events

EPA Grant Number: R827354C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R827354
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Rochester PM Center
Center Director: Oberdörster, Günter
Title: Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events
Investigators: Oberdörster, Günter , Zareba, Wojciech , Elder, Alison C.P. , Morrow, P. E. , Utell, Mark J. , Finkelstein, Jacob N. , Frampton, Mark W. , Cox, Christopher , Couderc, Jean-Philippe , Gelein, Robert , Kreyling, Wolfgang
Current Investigators: Oberdörster, Günter , Elder, Alison C.P.
Institution: University of Rochester
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The objective of this research project is to improve the generation system for laboratory-generated ultrafine carbon particles, specifically, to eliminate organic contaminants and set up a separate system for the generation of ultrafine organic particles and mixed ultrafine carbon/iron particles.

Approach:

We will conduct several animal studies, to continue work on our general hypothesis that pre-existing inflammation and old age are important priming factors to sensitize the host for subsequent pulmonary and cardiovascular effects of inhaled ultrafine particles. The in vivo endpoints to be evaluated include pulmonary inflammatory markers, analysis of blood white cell adhesion molecules, blood coagulation factors, heart rate variability, and blood pressure variability (BP).

Expected Results:

We expect to be able to extend the use of our animal models to exposures of ambient ultrafine particles and organic ultrafine carbonaceous particles.

Publications and Presentations:

Publications have been submitted on this subproject: View all 33 publications for this subproject | View all 106 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 27 journal articles for this subproject | View all 91 journal articles for this center

Supplemental Keywords:

animal model, dosimetry, pulmonary, cardiovascular, ultrafine carbon particle, UFP, particulate matter, PM, electrocardiogram, ECG, hypertensive, rat, heart rate variability, HRV., RFA, Scientific Discipline, Health, Air, Toxicology, particulate matter, Environmental Chemistry, Health Risk Assessment, air toxics, Risk Assessments, Biochemistry, Atmospheric Sciences, Molecular Biology/Genetics, ambient air quality, cytokine production, particle size, particulates, sensitive populations, biostatistics, health effects, risk assessment, cardiopulmonary responses, fine particles, human health effects, morbidity, ambient air monitoring, lung, cardiovascular vulnerability, pulmonary disease, susceptible populations, animal model, ambient air, environmental health effects, particle exposure, ambient monitoring, particulate exposure, lung inflamation, pulmonary, coronary artery disease, inhalation toxicology, tropospheric ozone, urban air pollution, mortality, urban environment, aerosol, cardiopulmonary, human health, aerosols, cardiovascular disease, ultrafine particles, pathophysiological mechanisms

Progress and Final Reports:

Main Center Abstract and Reports:

R827354 Rochester PM Center

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827354C001 Characterization of the Chemical Composition of Atmospheric Ultrafine Particles
R827354C002 Inflammatory Responses and Cardiovascular Risk Factors in Susceptible Populations
R827354C003 Clinical Studies of Ultrafine Particle Exposure in Susceptible Human Subjects
R827354C004 Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events
R827354C005 Ultrafine Particle Cell Interactions: Molecular Mechanisms Leading to Altered Gene Expression
R827354C006 Development of an Electrodynamic Quadrupole Aerosol Concentrator
R827354C007 Kinetics of Clearance and Relocation of Insoluble Ultrafine Iridium Particles From the Rat Lung Epithelium to Extrapulmonary Organs and Tissues (Pilot Project)
R827354C008 Ultrafine Oil Aerosol Generation for Inhalation Studies

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.