Grantee Research Project Results
Probabilistic Analysis of Fieldworker Exposure to Azinphosmethyl
EPA Grant Number: U915309Title: Probabilistic Analysis of Fieldworker Exposure to Azinphosmethyl
Investigators: Doran, Ed
Institution: University of Washington
EPA Project Officer: Hahn, Intaek
Project Period: September 1, 1998 through September 1, 2000
Project Amount: $58,277
RFA: STAR Graduate Fellowships (1998) RFA Text | Recipients Lists
Research Category: Fellowship - Health Risk Assessment , Academic Fellowships , Human Health
Objective:
The objective of this research project is to critically analyze the tools that are available to predict absorbed dose following dermal exposure to pesticide residues.
Approach:
The models used in these analyses were originally developed to estimate the dermal exposure of row crop workers to pesticide residues. We subsequently validated the models using data collected from a University of Washington field study of apple thinners. The following study expands our analyses by characterizing the accuracy, uncertainty, and variability of the model predictions. The distributions used in these analyses were drawn from comprehensive field studies of orchard worker exposures sponsored by either the University of Washington or the California Environmental Protection Agency. For these analyses, absorbed dose was calculated by coupling the concentration of pesticides on foliage with a transfer factor, a dermal absorption factor, the time exposed, and the personal characteristics of the workers. These parameters were entered into a standard exposure assessment model to estimate the absorbed daily dose. However, if absorption occurs until the materials are completely removed from the worker’s skin, a cumulative model may be used to calculate dermal uptake during and after the work shift. Both the standard and cumulative models were analyzed using a two-dimensional Monte Carlo protocol to determine the variability and uncertainty of the predictions. The predictions generated by the models were validated by comparing the estimated body burden to the dose represented by urinary metabolites.
Supplemental Keywords:
fellowship, exposure, pesticide, dermal, absorption, organophosphate, risk, orchard workers, apple thinners, Monte Carlo protocol, exposure assessment model, urinary metabolites., RFA, Health, Scientific Discipline, Ecosystem Protection/Environmental Exposure & Risk, Geographic Area, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, State, Biology, genetic susceptability, Monitoring/Modeling, Biochemistry, Disease & Cumulative Effects, Human Health Risk Assessment, population-based, California (CA), pesticides, cumulative exposure, pesticide residue, human exposure, organophosphate pesticides, pesticide exposure, risk assessment, Washington (WA), measurement , pesticides on foilage (DFR), dermal contact, pesticide residues, organophosphorous, cumulative risk, dermal exposure, absorption, cumulative absorption model, field workers, human health risk, population based studyProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.