Grantee Research Project Results
Signal Amplification of Nonextractive Immunoassay
EPA Contract Number: 68D60030Title: Signal Amplification of Nonextractive Immunoassay
Investigators: Thomas, Rhys N.
Small Business: Fayette Environmental Services Inc.
EPA Contact: Richards, April
Phase: I
Project Period: September 1, 1996 through March 1, 1997
Project Amount: $70,000
RFA: Small Business Innovation Research (SBIR) - Phase I (1996) RFA Text | Recipients Lists
Research Category: Ecological Indicators/Assessment/Restoration , SBIR - Monitoring , Small Business Innovation Research (SBIR)
Description:
Nonextractive immunoassay for analysis of soils and sediments for compounds of environmental interest has been shown to be sensitive and precise for most applications. Of particular value is the fact that nonextractive immunoassay uses no toxic solvents and generates no wastes. Being a noncompetitive enzyme-linked immunoassay, the detection limit is governed by the ability to differentiate small quantities of signal from the background. An increase in signal strength of several orders of magnitude may be gained by covalently binding novel, signal-amplifying functionalities to the antibodies. This project will develop and evaluate a signal amplified nonextractive immunoassay for inexpensive field assay of contaminated soils and sediments with detection limits in the low part per trillion range.Supplemental Keywords:
small business, SBIR, engineering, chemistry, biosensors, pesticide residues, hazardous waste., RFA, Scientific Discipline, Toxics, Water, Waste, Ecosystem Protection/Environmental Exposure & Risk, Environmental Chemistry, Contaminated Sediments, Chemistry, pesticides, Monitoring/Modeling, Analytical Chemistry, Environmental Monitoring, Environmental Engineering, biosensing, monitoring, nonextractive immunoassay, sediment bioassay, sediment treatment, assays, field portable monitoring, contaminated sediment, hazardous waste, biosensing system, remediation, pesticide residue, signal amplification, biosensor, biosensorsProgress and Final Reports:
SBIR Phase II:
Signal Amplification of Nonextractive ImmunoassayThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.