Grantee Research Project Results
A Randomized, Controlled Trial of Home Exposure Control in Asthma
EPA Grant Number: R826724C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R826724
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: A Randomized, Controlled Trial of Home Exposure Control in Asthma
Investigators: Eggleston, Peyton A.
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
This community-based prevention research project will conduct a randomized controlled trial of the effectiveness of current intervention methods to reduce hazardous exposures and their adverse health effects. It will test a global intervention that is composed of several components that have already proven to be effective in middle class homes. The major outcome of this trial will not be changes in health status but will be environmental exposure and it will examine the feasibility of modifying inner city home environments with currently recommended procedures. Data on the child's health status will also be collected, but it is anticipated that future studies with interventions that have already been proven effective will be necessary to provide adequate power to test a health outcome. Families in the Epidemiologic project will be asked to participate in the intervention. If they are willing to participate in the intervention trial, they will be given a second informed consent and assent, and asked to return for a second clinic visit. This visit will serve as the baseline for the intervention trial, and the parent and child will sign the separate consent to participate. We will conduct a second baseline evaluation with a questionnaire, blood sample, spirometry and methacholine inhalation challenge. At the end of the evaluation, they will be randomly assigned to receive treatment or control group and that multiple contacts will be necessary to evaluate the effect of treatment. asthma morbidity once more, the child will inscribe a spirogram, and the family will be randomized to Treatment (n--50) or Control Group (n--50). Treatment Group will receive allergen-proof mattress and pillow encasings for the child's bed, a room air cleaner for the child's room, pest control services if needed, smoking cessation support, and environmental avoidance education. All families will receive two home visits at 6 and 12 months, a telephone interview at 3, 6, 9, and 12 months and a final clinic evaluation.Supplemental Keywords:
children, health, asthma, exposure, allergic, PM, particulate matter., RFA, Health, Air, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, particulate matter, Biology, genetic susceptability, Environmental Chemistry, Allergens/Asthma, Children's Health, indoor air, indoor air quality, childhood respiratory disease, epidemeology, health effects, Human Health Risk Assessment, asthma morbidity, air quality, environmental hazard exposures, sensitive populations, allergen, asthma, indoor environment, biological response, antigen, human exposure, household, morbidity, children, exposure, PM, allergic response, ambient air, intervention, airborne pollutants, home, assessment of exposure, air pollution, human health risk, airway diseaseProgress and Final Reports:
Main Center Abstract and Reports:
R826724 Center for the Study of Childhood Asthma in the Urban Environment Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826724C001 A Randomized, Controlled Trial of Home Exposure Control in Asthma
R826724C002 Mechanisms Of Particulate-Induced Allergic Asthma
R826724C003 Genetic Mechanisms of Susceptibility to Inhaled Pollutants
R826724C004 The Relationship Of Airborne Pollutants And Allergens To Asthma Morbidity
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.