Grantee Research Project Results
Developmental Neurotox Assay Using Scalable Neurons and Astrocytes in High-Content Imaging
EPA Contract Number: EPD13018Title: Developmental Neurotox Assay Using Scalable Neurons and Astrocytes in High-Content Imaging
Investigators: Majumder, Anirban
Small Business: ArunA Biomedical, Inc.
EPA Contact: Richards, April
Phase: I
Project Period: May 15, 2013 through November 14, 2013
Project Amount: $79,993
RFA: Small Business Innovation Research (SBIR) - Phase I (2013) RFA Text | Recipients Lists
Research Category: Small Business Innovation Research (SBIR) , SBIR - Innovation in Manufacturing
Description:
The objective of this proposed project and the EPA Computational Toxicology program’s goals are aligned in assessing chemicals for potential risk to human health and the environment through the use of more representative multicellular human developmental neurotoxicology assays. ArunA Biomedical will develop a rapid, scalable, human pluripotent stem cell-derived cell-based coculture assay system to address a critical gap where animal developmental neurotoxicity testing for a single compound can be financially prohibitive (in excess of $1 million) and time consuming (up to 1.5 yrs). ArunA will manufacture pluripotent stem cell-derived neural cells using a patented system to generate functional neurons and astrocyte cultures, more closely mimicking the developing human nervous system than single cell-type assays.
Supplemental Keywords:
Astrocytes, Neurons, Neurotoxicology, Stem Cells, Neurotoxicity AssayProgress and Final Reports:
SBIR Phase II:
Developmental Neurotox Assay using Scalable Neurons and Astrocytes in High Content Imaging | Final ReportThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.