Final Report: Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition

EPA Grant Number: R834798C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R834798
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Air Pollution Mixtures: Health Effects across Life Stages
Center Director: Koutrakis, Petros
Title: Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition
Investigators: Gold, Diane R. , Gillman, Matthew , Oken, Emily , Schwartz, Joel
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2015 (Extended to December 31, 2016)
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The main aim of this project is to determine the health effects of prenatal and postnatal exposures to individual pollutants, sources, and pollutant mixtures on somatic growth, cardiovascular risk (blood pressure, exercise tolerance) and cognition in children. The strength of chronic and acute effects of individual pollutants will vary by source and mixture, as well as the timing of prenatal and postnatal exposures. Increased vulnerability or susceptibility to pollution effects on these adverse health outcomes will also result from socioeconomic disparities, stress and violence, environmental tobacco smoke, and reduced maternal and child omega-3 fatty acid intake measured in the prenatal as well as postnatal periods. Our Advisory Committee recommended including asthma as an outcome, and evaluating genetic variants as sources for susceptibility.

Summary/Accomplishments (Outputs/Outcomes):

We have demonstrated and have published findings on chronic (and for some outcomes, short term) effects of individual pollutants, sources and pollutant mixtures on birth weight, blood pressure, neurocognitive, and behavioral outcomes in children from Project Viva. We have also demonstrated chronic effects of pollutants on early life respiratory infection, wheeze, lung function and development of asthma. We have investigated and have reported findings regarding potential effect modifers including socioeconomic status, stress, tobacco smoke and nutrients, including vitamin D and omega-3 fatty acids. We have found local pollution effects on maternal glucose control during pregnancy and are investigating effects on blood pressure trajectories and preeclampsia risk. We have evaluated intermediate inflammatory outcomes in the child, and their relation to pollutant exposures; a doctoral candidate Jill Hahn is currently completing an analysis on prenatal pollutant exposures and cytokine production at birth. Dr. Joanne Sordillo is evaluating mixtures of environmental exposures in early life, including pollutants, and their long-term effects on airway inflammation in the children. Dr. Abby Fleisch and her student are looking at combined effects of chemical toxicants and pollution on cardiometabolic outcomes, and are investigating effects of pollutants and their sources on growth trajectories. Dr. Mary Rice has a paper in submission demonstrating life-time pollution effects on asthma development that differ by sex. We have collaborated closely with all of the other Cores and Projects, and have published collaboratively with the entire Center team. We have now extended our Center work within the new nation-wide ECHO birth cohort initiative.

Conclusions:

Prenatal and postnatal exposures to individual pollutants, sources, and pollutant mixtures have long-term effects on somatic growth, cardiovascular risk (blood pressure, exercise tolerance) and cognition in children. The strength of chronic and acute effects of individual pollutants vary by source and mixture, as well as the timing of prenatal and postnatal exposures.


Journal Articles on this Report : 28 Displayed | Download in RIS Format

Other subproject views: All 49 publications 32 publications in selected types All 32 journal articles
Other center views: All 410 publications 347 publications in selected types All 347 journal articles
Type Citation Sub Project Document Sources
Journal Article Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, Silverman F, Gold D, Baccarelli AA. DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments. Journal of the American Heart Association 2013;2(3):e000212 (11 pp.). R834798 (2013)
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  • Journal Article Bottino CJ, Rifas-Shiman SL, Kleinman KP, Oken E, Redline S, Gold D, Schwartz J, Melly SJ, Koutrakis P, Gillman MW, Taveras EM. The association of urbanicity with infant sleep duration. Health & Place 2012;18(5):1000-1005. R834798 (2013)
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  • Journal Article Fleisch AF, Kloog I, Luttmann-Gibson H, Gold DR, Oken E, Schwartz JD. Air pollution exposure and gestational diabetes mellitus among pregnant women in Massachusetts: a Cohort Study. Environmental Health 2016;15(1):40 (9 pp.). R834798 (2016)
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  • Journal Article Fleisch AF, Luttmann‐Gibson H, Perng W, Rifas‐Shiman SL, Coull BA, Kloog I, Koutrakis P, Schwartz JD, Zanobetti A, Mantzoros CS, Gillman MW, Gold DR, Oken E. Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood. Pediatric Obesity 2017;12(1):48-57. R834798 (Final)
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  • Journal Article Gold DR, Mittleman MA. New insights into pollution and the cardiovascular system: 2010 to 2012. Circulation 2013;127(18):1903-1913. R834798 (2013)
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  • Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, Belfort MB, Webster TF, White RF, Sagiv SK, Oken E. Prenatal and childhood traffic-related air pollution exposure and childhood executive function and behavior. Neurotoxicology and Teratology 2016;57(Sep-Oct):60-70. R834798 (Final)
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  • Journal Article Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 2012;120(2):241-246. R834798 (2012)
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  • Journal Article Ierodiakonou D, Zanobetti A, Coull BA, Melly S, Postma DS, Boezen HM, Vonk JM, Williams PV, Shapiro GG, McKone EF, Hallstrand TS, Koenig JQ, Schildcrout JS, Lumley T, Fuhlbrigge AN, Koutrakis P, Schwartz J, Weiss ST, Gold DR, Childhood Asthma Management Program Research Group. Ambient air pollution, lung function, and airway responsiveness in asthmatic children. Journal of Allergy and Clinical Immunology 2016;137(2):390-399. R834798 (2015)
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  • Journal Article Li W, Dorans KS, Wilker EH, Rice MB, Long MT, Schwartz J, Coull BA, Koutrakis P, Gold DR, Fox CS, Mittleman MA. Residential proximity to major roadways, fine particulate matter, and hepatic steatosis: the Framingham Heart Study. American Journal of Epidemiology 2017;186(7):857-865. R834798 (Final)
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  • Journal Article Link MS, Luttmann-Gibson H, Schwartz J, Mittleman MA, Wessler B, Gold DR, Dockery DW, Laden F. Acute exposure to air pollution triggers atrial fibrillation. Journal of the American College of Cardiology 2013;62(9):816-825. R834798 (2013)
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  • Journal Article Mostofsky E, Schwartz J, Coull BA, Koutrakis P, Wellenius GA, Suh HH, Gold DR, Mittleman MA. Modeling the association between particle constituents of air pollution and health outcomes. American Journal of Epidemiology 2012;176(4):317-326. R834798 (2013)
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  • Journal Article Oken E, Baccarelli AA, Gold DR, Kleinman KP, Litonjua AA, De Meo D, Rich-Edwards JW, Rifas-Shiman SL, Sagiv S, Taveras EM, Weiss ST, Belfort MB, Burris HH, Camargo Jr. CA, Huh SY, Mantzoros C, Parker MG, Gillman MW. Cohort profile: Project Viva. International Journal of Epidemiology 2015;44(1):37-48. R834798 (Final)
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  • Journal Article Rice MB, Rifas-Shiman SL, Oken E, Gillman MW, Ljungman PL, Litonjua AA, Schwartz J, Coull BA, Zanobetti A, Koutrakis P, Melly SJ, Mittleman MA, Gold DR. Exposure to traffic and early life respiratory infection: a cohort study. Pediatric Pulmonology 2015;50(3):252-259. R834798 (2014)
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  • Journal Article Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, Gold DR, Lukic KZ, Speck M, Kusha M, Farid T, Poku K, Shi E, Floras J, Nanthakumar K. The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. Journal of the American College of Cardiology 2011;57(2):198-206. R834798 (2012)
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  • Journal Article Wilker EH, Ljungman PL, Rice MB, Kloog I, Schwartz J, Gold DR, Koutrakis P, Vita JA, Mitchell GF, Vasan RS, Benjamin EJ, Hamburg NM, Mittleman MA. Relation of long-term exposure to air pollution to brachial artery flow-mediated dilation and reactive hyperemia. American Journal of Cardiology 2014;113(12):2057-2063. R834798 (2014)
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  • Journal Article Zanobetti A, Luttmann-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR. Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study. Environmental Health Perspectives 2014;122(3):242-248. R834798 (2013)
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  • Journal Article Zanobetti A, Coull BA, Kloog I, Sparrow D, Vokonas PS, Gold DR, Schwartz J. Fine-scale spatial and temporal variation in temperature and arrhythmia episodes in the VA Normative Aging Study. Journal of the Air & Waste Management Association 2017;67(1):96-104. R834798 (Final)
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  • Journal Article Zhong J, Urch B, Speck M, Coull BA, Koutrakis P, Thorne PS, Scott J, Liu L, Brook RD, Behbod B, Gibson H, Silverman F, Mittlemanm MA, Baccarelli AA, Gold DR. Endotoxin and β-1,3-d-glucan in concentrated ambient particles induce rapid increase in blood pressure in controlled human exposures. Hypertension 2015;66(3):509-516. R834798 (2016)
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  • Journal Article Zhong J, Trevisi L, Urch B, Lin X, Speck M, Coull BA, Liss G, Thompson A, Wu S, Wilson A, Koutrakis P, Silverman F, Gold DR, Baccarelli AA. B-vitamin supplementation mitigates effects of fine particles on cardiac autonomic dysfunction and inflammation: a pilot human intervention trial. Scientific Reports 2017;7:45322 (9 pp.). R834798 (Final)
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  • Journal Article Zhong J, Karlsson O, Wang G, Li J, Guo Y, Lin X, Zemplenyi M, Sanchez-Guerra M, Trevisi L, Urch B, Speck M, Liang L, Coull BA, Koutrakis P, Silverman F, Gold DR, Wu T, Baccarelli AA. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. Proceedings of the National Academy of Sciences of the United States of America 2017;114(13):3503-3508. R834798 (Final)
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  • Journal Article Ljungman PL, Wilker EH, Rice MB, et al. Short-term exposure to air pollution and digital vascular function. Am J Epidemiol. 2014a;180:482-489. R834798C003 (Final)
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  • Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Belfort MB, Webster TF,. R834798C004 (Final)
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    Journal Article Peng C, Luttmann-Gibson H, Zanobetti A, Cohen A, De Souza C, Coull BA, Horton ES, Schwartz J, Koutrakis P, Gold DR. Air pollution influences on exhaled nitric oxide among people with type 2 diabetes. Air Quality, Atmosphere and Health. http://link.springer.com/article/10.1007%2Fs11869-015-0336-5Mar 26, 2015. R834798C004 (Final)
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    Journal Article Rice MB, Ljungman PL, Wilker EH, et al. Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham Heart Study. Am J Respir Crit Care Med. 2015;191:656-664. R834798C003 (Final)
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    Journal Article Fleisch A, Luttmann-Gibson H, Perng W, Rifas-Shiman S, Coull BA, Kloog I, Koutrakis P, Schwartz J, Zanobetti A, Mantzoros C, Gillman M, Gold DR, Oken E. Prenatal and Early Life Exposure to Traffic Pollution and Cardiometabolic Health in Childhood. Pediatric Obesity 2016; doi:10.1111/ijpo.12106:1-10. R834798 (2016)
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    Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Sagiv SK, Oken E. Prenatal and childhood exposure to traffic-related pollution and childhood cognition. Environ Health Perspect. 2015. Apr 3. [Epub ahead of print]. PMID:25839914. R834798C004 (Final)
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    Journal Article van Rossem L, Melly S, Rifas-Shiman SL, Melly S, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull B, Schwartz J, Mittleman M, Oken E, Gillman M, Koutrakis P, Gold DR. Prenatal exposure to air pollution and newborn blood pressure. Environ Health Perspect. 2015. Apr;123(4):353-9. doi:10.1289/ehp.1307419. Epub 2015 Jan 27.PMID:25625652. R834798C004 (Final)
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    Journal Article Fleisch AF, Rifas-Shiman SL, Koutrakis P, Schwartz J , Kloog I, Melly S, Coull B, Zanobetti A, Gillman M, Gold DR, Oken E. Prenatal exposure to traffic pollution:associations with reduced fetal growth and rapid infant weight gain. Epidemiology. 2015 Jan;26(1):43-50. doi:10.1097/EDE.0000000000000203.PMID:25437317. R834798C004 (Final)
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    Supplemental Keywords:

    Scientific Discipline, Air, air toxics, Health Risk Assessment, Air Pollution Effects, Biochemistry, Environmental Monitoring, Biology, ambient air quality, complex mixtures, health effects, sensitive populations, children's health, air pollutants, biological sensitivities, exposure and effects, lung epithelial cells, susceptible populations, chemical composition, neurotoxicity, human exposure, toxicity, coronary artery disease, cardiopulmonary, cardiotoxicity, environmental effects, mortality, human health

    Relevant Websites:

    The Harvard CLARC website, with links to investigators, projects, reports and publications can be found at:  Air Pollution Mixtures: Health Effects Across Life Stages Exit

    Progress and Final Reports:

    Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report

  • Main Center Abstract and Reports:

    R834798    Air Pollution Mixtures: Health Effects across Life Stages

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834798C001 Relative Toxicity of Air Pollution Mixtures
    R834798C002 Cognitive Decline, Cardiovascular Changes, and Biological Aging in Response to Air Pollution
    R834798C003 Identifying the Cognitive and Vascular Effects of Air Pollution Sources and Mixtures in the Framingham Offspring and Third Generation Cohorts
    R834798C004 Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition
    R834798C005 A National Study to Assess Susceptibility, Vulnerability, and Effect Modification of Air Pollution Health Risks