2003 Progress Report: Statistics and Data Core

EPA Grant Number: R827355C009
Subproject: this is subproject number 009 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Statistics and Data Core
Investigators: Sheppard, Lianne (Elizabeth) A. , Wakefield, Jon , Sampson, Paul , Lumley, Thomas
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2005)
Project Period Covered by this Report: June 1, 2002 through May 31, 2003
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The statistics and data core objectives are to: (1) compile and manage data to support Particulate Matter (PM) Center research; (2) utilize existing data for analyses of health effects; (3) ensure quality statistical design and analysis for PM Center research; and (4) identify statistical methodology research needs for PM Center research and seek resources to perform such research.

The statistical methods objectives are to: (1) develop and clarify statistical methodology in the air pollution field; and (2) perform specific projects, including using source-apportioned data in health effects analyses, interpreting exposure effects in chronic effect studies, utilizing case-crossover methods in air pollution, and performing spatiotemporal modeling of PM.

Progress Summary:

In the course of this research project, we have undertaken the following activities: (1) active ongoing support of the Agricultural Burning Study database management, data entry, data validation, and data analyses; (2) active ongoing support of management and analysis of Project 2c size-distributed data, including data management, data validation, data analyses, and development of new software and methods; (3) support of Project 3 animal exposure models—some data management, data organization, and statistical consulting; (4) active ongoing support of Project 1 epidemiology studies activities, particularly with respect to the Women’s Health Initiative Study, cystic fibrosis analysis, and Bronchiolitis Study (we are planning for potential new studies); (5) active ongoing support of the Project 2 Panel Study, particularly health effects analyses (heart rate variability, blood, lung), database management and validation of all years of data, and Year 4 of the project New York University initial data organization and data validation; (6) active ongoing support of the Biomarker Core research; and (7) active ongoing support of the Diesel Facility Project: data forms development, data organization, database management, data validation, technical systems review support, and statistical collaboration/support.

In addition, we are providing general support of data analyses and data sharing and performing statistical methods research, particularly in the areas of case-crossover studies, health effects study design, spatiotemporal modeling, and source apportionment. We also are collaborating with the Sydney Brush Fire Study to examine mortality displacement and providing ongoing implementation and support of statistical analysis plans (SAPs).

Future Activities:

We will: (1) continue with existing goals for statistical and data support of the Center and to actively support PM Center research through database management, analysis, statistical collaboration, and implementation of an SAP framework; (2) continue with a high level of productivity; (3) continue with statistical methods projects; (4) extend source apportionment and health effects methodological research to include the hierarchical Bayesian approach/Markov Chain Monte Carlo framework as a first step toward a fully integrated approach to health effects analysis, from species to health outcomes; (5) write a paper on air pollution panel studies entitled, “Statistical Issues With an Eye to Alternative Methods of Analysis”; and (6) integrate statistical methods into biomarker research (i.e., methodological issues associated with below detection level data).


Journal Articles on this Report : 12 Displayed | Download in RIS Format

Other subproject views: All 44 publications 30 publications in selected types All 29 journal articles
Other center views: All 209 publications 113 publications in selected types All 109 journal articles
Type Citation Sub Project Document Sources
Journal Article Allen R, Larson T, Sheppard L, Wallace L, Liu L-JS. Use of real-time light scattering data to estimate the contribution of infiltrated and indoor-generated particles to indoor air. Environmental Science & Technology 2003;37(16):3484-3492. R827355 (2004)
R827355 (Final)
R827355C003 (2003)
R827355C003 (Final)
R827355C008 (Final)
R827355C009 (2003)
  • Abstract from PubMed
  • Full-text: ResearchGate - Abstract & Full Text PDF
    Exit
  • Abstract: ACS-Abstract
    Exit
  • Other: ACS-Full Text PDF
    Exit
  • Journal Article Dominici F, Sheppard L, Clyde M. Health effects of air pollution: a statistical review. International Statistical Review 2003;71(2):243-276. R827355 (2004)
    R827355 (Final)
    R827355C009 (2002)
    R827355C009 (2003)
  • Abstract: Wiley-Abstract
    Exit
  • Other: Prepublication paper
    Exit
  • Journal Article Goss CH, Newsom SA, Schildcrout JS, Sheppard L, Kaufman JD. Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine 2004;169(7):816-821. R827355 (2004)
    R827355 (Final)
    R827355C001 (2003)
    R827355C009 (2003)
  • Abstract from PubMed
  • Full-text: AJRCCM-Full Text HTML
    Exit
  • Abstract: AJRCCM-Abstract
    Exit
  • Other: AJRCCM-Full Text PDF
    Exit
  • Journal Article Janes H, Sheppard L, Lumley T. Overlap bias in the case-crossover design, with application to air pollution exposures. Statistics in Medicine 2005;24(2):285-300. R827355 (2004)
    R827355 (Final)
    R827355C009 (2003)
    R827355C009 (Final)
  • Abstract from PubMed
  • Full-text: Core-Full Text Prepublication PDF
    Exit
  • Abstract: Wiley-Abstract
    Exit
  • Journal Article Kim E, Larson TV, Hopke PK, Slaughter C, Sheppard LE, Claiborn C. Source identification of PM2.5 in an arid Northwest U.S. city by positive matrix factorization. Atmospheric Research 2003;66(4):291-305. R827355 (2004)
    R827355 (Final)
    R827355C008 (2002)
    R827355C008 (Final)
    R827355C009 (2003)
    R827354 (Final)
    R827354C001 (Final)
    R828678C010 (2003)
    R828678C010 (2004)
    R828678C010 (2005)
    R828678C010 (2006)
    R828678C010 (2007)
    R828678C010 (Final)
    R832415 (2010)
    R832415 (2011)
    R832415 (Final)
  • Full-text: ScienceDirect-Full Text PDF
    Exit
  • Abstract: ScienceDirect-Abstract and Full Text HTML
    Exit
  • Other: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Koenig JQ, Jansen K, Mar TF, Lumley T, Kaufman J, Trenga CA, Sullivan J, Liu L-JS, Shapiro GG, Larson TV. Measurement of offline exhaled nitric oxide in a study of community exposure to air pollution. Environmental Health Perspectives 2003;111(13):1625-1629. R827355 (2004)
    R827355 (Final)
    R827355C002 (2002)
    R827355C002 (Final)
    R827355C003 (Final)
    R827355C009 (2003)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Sheppard L. Acute air pollution effects:consequences of exposure distribution and measurements. Journal of Toxicology and Environmental Health-Part A-Current Issues 2005;68(13-14):1127-1135. R827355 (2004)
    R827355 (Final)
    R827355C009 (2003)
    R827355C009 (Final)
  • Abstract from PubMed
  • Abstract: Taylor Francis Online
    Exit
  • Journal Article Sheppard L, Slaughter JC, Schildcrout J, Liu L-JS, Lumley T. Exposure and measurement contributions to estimates of acute air pollution effects. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(4):366-376. R827355 (2004)
    R827355 (Final)
    R827355C009 (2003)
    R827355C009 (Final)
  • Abstract from PubMed
  • Full-text: NATURE-Full Text HTML
    Exit
  • Other: NATURE-Full Text PDF
    Exit
  • Journal Article Slaughter JC, Koenig JQ, Reinhardt TE. Association between lung function and exposure to smoke among firefighters at prescribed burns. Journal of Occupational and Environmental Hygiene 2004;1(1):45-49. R827355 (Final)
    R827355C002 (2004)
    R827355C002 (Final)
    R827355C009 (2003)
  • Abstract from PubMed
  • Abstract: Taylor and Francis-Abstract
    Exit
  • Journal Article Slaughter JC, Kim E, Sheppard L, Sullivan JH, Larson TV, Claiborn C. Association between particulate matter and emergency room visits, hospital admissions and mortality in Spokane, Washington. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(2):153-159. R827355 (Final)
    R827355C008 (Final)
    R827355C009 (2002)
    R827355C009 (2003)
    R827355C009 (Final)
    R828678C010 (2003)
    R828678C010 (2004)
    R828678C010 (2005)
    R828678C010 (2006)
    R828678C010 (2007)
    R828678C010 (Final)
  • Abstract from PubMed
  • Full-text: JESEE-Full Text PDF
    Exit
  • Abstract: JESEE-Abstract & Full Text HTML
    Exit
  • Other: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Sullivan JH, Schreuder AB, Trenga CA, Liu SL, Larson TV, Koenig JQ, Kaufman JD. Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease. Thorax 2005;60(6):462-466. R827355 (Final)
    R827355C001 (Final)
    R827355C009 (2003)
    R827355C009 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Thorax-Full Text HTML
    Exit
  • Abstract: Thorax-Abstract
    Exit
  • Other: Thorax-Full Text PDF
    Exit
  • Journal Article Sullivan J, Sheppard L, Schreuder A, Ishikawa N, Siscovick D, Kaufman J. Relation between short-term fine-particulate matter exposure and onset of myocardial infarction. Epidemiology 2005;16(1):41-48. R827355 (Final)
    R827355C001 (2003)
    R827355C001 (Final)
    R827355C009 (2003)
    R827355C009 (Final)
  • Abstract from PubMed
  • Full-text: LWW-Full Text HTML
    Exit
  • Abstract: LWW-Abstract
    Exit
  • Other: LWW-Full Text PDF
    Exit
  • Supplemental Keywords:

    ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility, human susceptibility, sensitive populations, air toxics, genetic susceptibility, indoor air, indoor air quality, indoor environment, tropospheric ozone, California, CA, polyaromatic hydrocarbons, PAHs, hydrocarbons, acute cardiovascular effects, aerosols, air pollutants, air pollution, air quality, airborne pollutants, airway disease, airway inflammation, allergen, ambient aerosol, ambient aerosol particles, ambient air, ambient air quality, ambient particle health effects, animal model, assessment of exposure, asthma, atmospheric aerosols, atmospheric chemistry, biological markers, biological response, cardiopulmonary response, cardiovascular disease, children, children’s vulnerability, combustion, combustion contaminants, combustion emissions, epidemiology, exposure, exposure and effects, exposure assessment, harmful environmental agents, hazardous air pollutants, health effects, health risks, human exposure, human health effects, human health risk, incineration, inhalation, lead, morbidity, mortality, mortality studies, particle exposure, particle transport, particulates, particulate matter, risk assessment,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, Geographic Area, particulate matter, air toxics, Environmental Chemistry, Health Risk Assessment, Air Pollutants, Epidemiology, State, Air Pollution Effects, Northwest, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Physical Processes, genetic susceptability, Atmospheric Sciences, Risk Assessment, ambient aerosol, ambient air quality, biostatistics, health effects, particulates, sensitive populations, cardiopulmonary responses, health risks, human health effects, morbidity, toxicology, exposure and effects, acute cardiovascular effects, dose-response, exposure, hazardous air pollutants, epidemelogy, air pollution, Human Health Risk Assessment, particle exposure, cardiopulmonary response, human exposure, inhalation, atmospheric aerosols, ambient particle health effects, mortality studies, air pollutant, PM, human susceptibility, mortality, California (CA), biomarker based exposure inference, aerosols, air quality, atmospheric chemistry, cardiovascular disease, exposure assessment, human health risk, biomarker, particle transport, toxics

    Relevant Websites:

    http://depts.washington.edu/pmcenter/ Exit

    Progress and Final Reports:

    Original Abstract
  • 1999
  • 2000
  • 2001
  • 2002 Progress Report
  • Final Report

  • Main Center Abstract and Reports:

    R827355    Airborne PM - Northwest Research Center for Particulate Air Pollution and Health

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
    R827355C002 Health Effects
    R827355C003 Personal PM Exposure Assessment
    R827355C004 Characterization of Fine Particulate Matter
    R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
    R827355C006 Toxicology Project -- Controlled Exposure Facility
    R827355C007 Health Effects Research Core
    R827355C008 Exposure Core
    R827355C009 Statistics and Data Core
    R827355C010 Biomarker Core
    R827355C011 Oxidation Stress Makers