2002 Progress Report: Cardiopulmonary Effects of Metal-Containing Particulate ExposureEPA Grant Number: R828678C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R824834
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Mickey Leland National Urban Air Toxics Research Center (NUATRC)
Center Director: Beskid, Craig
Title: Cardiopulmonary Effects of Metal-Containing Particulate Exposure
Investigators: Christiani, David
Institution: Harvard T.H. Chan School of Public Health
EPA Project Officer: Chung, Serena
Project Period: January 1, 1999 through January 31, 2004
Project Period Covered by this Report: January 1, 2001 through January 31, 2002
RFA: Mickey Leland National Urban Air Toxics Research Center (NUATRC) (1997) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Targeted Research
The objective of this research project is to investigate the role of respirable particulate matter (PM2.5) and associated metals in respiratory and cardiovascular responses in a cohort of boilermakers with and without chronic bronchitis. The experimental approach is an epidemiological study employing a prospective, repeat-measurement design assessing several biological parameters in relation to exposure. PM2.5 levels will be monitored continuously with personal Dust Trak monitors. Personal metal exposure (V, N, Cd, Mn, Cr, and Fe) will be measured daily. Boilermaker exposure to the fuel oil ash particulate will be related to the following: (1) airway inflammation, by measuring daily exhaled NO; (2) airflow obstruction, by measuring daily peak flow and weekly lung function (FEV1); and (3) cardiovascular function, by measuring daily heart rate, heart rate variability, and blood pressure.
Workers during pre-exposure (layoff) serve as their own controls. Subjects with chronic bronchitis are being compared to nonsymptomatic subjects. This project is leveraged with funds from a National Institute of Environmental Health Sciences (NIEHS) grant.
This project was developed in response to NUATRC Request for Application 98-02, "Contribution of Metals in Ambient Particles to the Particulate Associated Health Effects." The study is in compliance with the Institutional Review Board of the Harvard School of Public Health. Human consent procedures met governmental guidelines. The study also is in compliance with appropriate NUATRC and U.S. Environmental Protection Agency quality assurance/quality control guidelines.
Boilermakers (N = 40) have been monitored both in the field, at the site of two boiler overhauls, and at the apprentice welding school. Continuous monitoring of exposure and heart rate variability, and spirometry and exhaled nitric oxide, was performed during and away from work.
In Year 2 of the project, the investigator completed sampling and data collection for the study, as well as sampling and analyses of the filters for particulate matter and metals. Metals analyses in the urine also were completed during this period. Data analyses for the study were completed as well. A draft final report for the study was received in December 2002. The report currently is being reviewed by a team of external peer reviewers.
Preliminary Results and Conclusions From the Study
The fractional concentration of expired NO in mixed expired air (FeNO) during the work week was found to be significantly lower than baseline FeNO in the group sampled during 1999, after adjusting for smoking status, age, and sampling year. However, there was lack of an exposure-response relationship between PM2.5 exposure and FeNO in 2000. This was attributed to exposure misclassification resulting from the use of respirators. A statistically significant inverse exposure-response relationship was found between FeNO and PM2.5 vanadium, chromium, manganese, and nickel exposure in the boilermakers. Linear mixed effect models showed that high levels of urinary metal Ni, Mn, Ni, and Pb at various lag times, after adjusting for smoking status, lead to significant decrease in FeNO. This suggests that exposure to metals may affect respiratory health.
The investigators then focused on the associations between PM2.5 and the metallic component and cardiac autonomic function based on heart rate and heart rate variability measures. The investigators used mixed-effects models to regress heart rate and standard deviation of the normal-to-normal (SDNN) index on PM2.5 and five metals (V, Ni, Pd, Cu, and Mn). Workers experienced altered cardiac autonomic control after exposure to occupational and environmental PM2.5. The investigators conclude that there appears to be either a long-acting (several hours) and a short-acting (several minutes) component to the mechanism of action that may be related to the production of cytokines and the sympathetic stress response, respectively, or a cumulative effect that begins shortly after exposure begins. There were statistically significant mean increases in the SDNN index of 11.30 msec and 3.98 msec for every 1 µg/m3 increase in Pb and V concentrations, respectively, after adjusting for heart rate, age, and smoking status. Small changes in mean heart rate were seen with all exposure metrics. The results suggest an association between cardiac effects and exposure to airborne metals.
We will conduct an external peer review of the draft final report, revise it accordingly, and submit it to EPA.
Journal Articles on this Report : 3 Displayed | Download in RIS Format
|Other subproject views:||All 17 publications||6 publications in selected types||All 6 journal articles|
|Other center views:||All 144 publications||62 publications in selected types||All 53 journal articles|
||Kim JY, Wand MP, Hauser R, Mukherjee S, Herrick RF, Christiani DC. Association of expired nitric oxide with occupational particulate exposure. Environmental Health Perspectives 2003;111(5):676-680.||
||Magari SR, Schwartz J, Williams PL, Hauser R, Smith TJ, Christiani DC. The association between personal measurements of environmental exposure to particulates and heart rate variability. Epidemiology 2002;13(3):305-310.||
||Magari SR, Schwartz J, Williams PL, Hauser R, Smith TJ, Christiani DC. The association of particulate air metal concentrations with heart rate variability. Environmental Health Perspectives 2002;110(9):875-880.||
Supplemental Keywords:particulate matter, PM2.5, boilermakers, boilermaker exposure, airway inflammation, airflow obstruction, cardiovascular function, standard deviation of the normal-to-normal index, SDNN., RFA, Health, Scientific Discipline, Air, HUMAN HEALTH, particulate matter, air toxics, Environmental Chemistry, Health Risk Assessment, Exposure, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, genetic susceptability, Atmospheric Sciences, Biology, copollutant exposures, sensitive populations, atmospheric particulate matter, cardiopulmonary responses, fine particles, morbidity, PM 2.5, long term exposure, inhaled pollutants, acute lung injury, acute cardiovascular effects, air pollution, chemical mixtures, susceptible subpopulations, cardiac arrest, cardiopulmonary response, chronic health effects, human exposure, lung inflammation, particulate exposure, time series analysis, National Cohort Studies, Acute health effects, inhaled, human susceptibility, cardiopulmonary, cardiotoxicity, mortality, acute exposure, air quality, cardiovascular disease, human health risk, toxics, environmental hazard exposures, air contaminant exposure, co-pollutants
Progress and Final Reports:Original Abstract
Main Center Abstract and Reports:R824834 Mickey Leland National Urban Air Toxics Research Center (NUATRC)
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R824834C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles - A Columbia-Harvard Study (TEACH)
R824834C002 Cardiopulmonary Response to Particulate Exposure
R824834C003 VOC Exposure in an Industry Impacted Community
R824834C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
R824834C005 Methods Development Project for a Study of Personal Exposures to Toxic Air Pollutants
R824834C006 Relationship Between Indoor, Outdoor and Personal Air (RIOPA)
R824834C007 Development of the "Leland Legacy" Air Sampling Pump
R824834C008 Source Apportionment of Indoor Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Residences
R824834C009 Development of a Personal Cascade Impactor Sampler (PCIS)
R824834C010 Testing the Metals Hypothesis in Spokane
R828678C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles—A Columbia-Harvard Study (TEACH)
R828678C002 Cardiopulmonary Effects of Metal-Containing Particulate Exposure
R828678C003 VOC Exposure in an Industry Impacted Community
R828678C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
R828678C005 Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)
R828678C006 Relationship between Indoor, Outdoor and Personal Air (RIOPA). Part II: Analyses of Concentrations of Particulate Matter Species
R828678C007 Development of the “Leland Legacy” Air Sampling Pump
R828678C008 Source Apportionment of Indoor PAHs in Urban Residences 98-03B
R828678C009 Development of a Personal Cascade Impactor Sampler (PCIS)
R828678C010 Testing the Metals Hypothesis in Spokane
R828678C011 A Pilot Geospatial Analysis of Exposure to Air Pollutants (with Special Attention to Air Toxics) and Hospital Admissions in Harris County, Texas
R828678C012 Impact of Exposure to Urban Air Toxics on Asthma Utilization for the Pediatric Medicaid Population in Dearborn, Michigan
R828678C013 Field Validation of the Sioutas Sampler and Leland Legacy Pump – Joint Project with EPA’s Environmental Technology Validation Program (ETV)
R828678C014 Performance Evaluation of the 3M Charcoal Vapor Monitor for Monitor Low Ambient Concentrations of VOCs
R828678C015 RIOPA Database Development
R828678C016 Contributions of Outdoor PM Sources to Indoor and Personal Exposures: Analysis of PM Species Concentrations” Focused on the PM Speciation and Apportioning of Sources
R828678C017 The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children