Final Report: Determining the Effects of Particle Characteristics on Respiratory Health of Children

EPA Grant Number: R827353C007
Subproject: this is subproject number 007 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Determining the Effects of Particle Characteristics on Respiratory Health of Children
Investigators: Dockery, Douglas W. , Luttmann-Gibson, Heike
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air


Theme II: Identifying Populations Susceptible to the Health Effects of Particulate Air Pollution

The main objective of this project was to examine the effects of particle composition on the respiratory health of children using particulate matter (PM) samples collected as part of the Harvard 24-Cities study.

Summary/Accomplishments (Outputs/Outcomes):

The Harvard 24-Cities Study assessed respiratory health and particle exposures of 13,364 fourth and fifth grade school children in the United States and Canada between 1988 and 1991. The University of Southern California Children’s Health Study had similarly assessed respiratory health and particle exposures of approximately 4000 fourth and fifth grade school children in twelve communities in Southern California. The Harvard study was designed to assess effects of power plant particles, while the Southern California Study focuses on effects from mobile source particles. The Harvard Study included one Southern California community (Simi Valley) and two other California sites (Monterey and Livermore).

The chemical analysis and data processing of the 24-Cities samples was completed. The statistical analysis of the exposure and health data was initiated, but it was not completed. Preliminary results of this analysis presented in the 2003 Science Advisory Committee (SAC) meeting, showed no association between air pollution-caused respiratory effects and elemental carbon concentrations. We planned to conduct a collaborative inter-center assessment of the effects of chronic particulate exposures on respiratory health of children. We expected that pooling these studies will greatly improve our ability to assess the relative contribution of power plant versus mobile source particles on respiratory health of children. These additional analyses have not been completed.

Supplemental Keywords:

RFA, Health, Scientific Discipline, Air, Geographic Area, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, State, Risk Assessments, Microbiology, Susceptibility/Sensitive Population/Genetic Susceptibility, Environmental Microbiology, Environmental Monitoring, Children's Health, genetic susceptability, indoor air, Atmospheric Sciences, Molecular Biology/Genetics, Biology, ambient air quality, health effects, interindividual variability, molecular epidemiology, monitoring, particulates, risk assessment, sensitive populations, chemical exposure, air pollutants, cardiopulmonary responses, health risks, human health effects, indoor exposure, PM 2.5, ambient air monitoring, exposure and effects, ambient air, ambient measurement methods, exposure, lead, pulmonary disease, developmental effects, Georgia (GA), epidemelogy, biological response, respiratory disease, air pollution, ambient monitoring, children, Human Health Risk Assessment, Massachusetts (MA), particle exposure, biological mechanism , cardiopulmonary response, human exposure, inhalation, pulmonary, susceptibility, Maryland (MD), particulate exposure, assessment of exposure, ambient particle health effects, epidemeology, human susceptibility, environmental health hazard, inhalation toxicology, cardiopulmonary, indoor air quality, inhaled particles, human health, California (CA), air quality, cardiovascular disease, dosimetry, exposure assessment, human health risk, respiratory, genetic susceptibility

Relevant Websites: Exit

Progress and Final Reports:

Original Abstract
  • 1999
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003
  • 2004

  • Main Center Abstract and Reports:

    R827353    EPA Harvard Center for Ambient Particle Health Effects

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
    R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
    R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
    R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
    R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
    R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
    R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
    R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
    R827353C009 Assessing Deposition of Ambient Particles in the Lung
    R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
    R827353C011 Studies of Oxidant Mechanisms
    R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
    R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
    R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
    R827353C015 Research Coordination Core
    R827353C016 Analytical and Facilities Core
    R827353C017 Technology Development and Transfer Core