Immunologic Basis of Environmental Lung Disease

EPA Grant Number: R825702
Center: Environmental Lung Disease Center (National Jewish Medical and Research Center)
Center Director: Mason, Robert J.
Title: Immunologic Basis of Environmental Lung Disease
Investigators: Mason, Robert J.
Current Investigators: Mason, Robert J. , Gelfand, Erwin , Rabinovitch, Nathan , White, Carl W.
Institution: National Jewish Medical and Research Center
EPA Project Officer: Chung, Serena
Project Period: February 16, 1998 through February 28, 2003 (Extended to February 28, 2004)
Project Amount: $7,269,177
RFA: Environmental Lung Disease Center (National Jewish Medical and Research Center) (1998) RFA Text |  Recipients Lists
Research Category: Targeted Research

Objective:

The objectives of the Environmental Lung Disease Center are to improve the understanding of lung disease, and develop innovative early disease detection, prevention and treatment approaches. The center's research involves: 1) determining the molecular mechanisms of environmental and occupational lung disease, 2) identifying the genetic and molecular basis for individual susceptibility, and 3) identifying the risk and effects of air pollution on human population with preexisting pulmonary diseases, and the exposure/host response relationship that leads to disease. Besides immunologic diseases, the project will focus on respiratory, allergic, and infectious diseases, through an integrated program of basic and clinical research.


Journal Articles: 110 Displayed | Download in RIS Format

Other center views: All 132 publications 111 publications in selected types All 110 journal articles
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Journal Article Ahmad A, Ahmad S, Chang L-Y, Schaack J, White CW. Endothelial Akt activation by hyperoxia: role in cell survival. Free Radical Biology and Medicine 2006;40(7):1108-1118. R825702 (Final)
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  • Journal Article Ahmad S, Ahmad A, Ghosh M, Leslie CC, White CW. Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. The Journal of Biological Chemistry 2004;279(16):16317-16325. R825702 (Final)
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  • Journal Article Ahmad S, Ahmad A, McConville G, Schneider BK, Allen CB, Manzer R, Mason RJ, White CW. Lung epithelial cells release ATP during ozone exposure: signaling for cell survival. Free Radical Biology and Medicine 2005;39(2):213-226. R825702 (Final)
    R825702C014 (Final)
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  • Journal Article Ahmad S, Ahmad A, Schneider BK, White CW. Cholesterol interferes with the MTT assay in human epithelial-like (A549) and endothelial (HLMVE and HCAE) cells. International Journal of Toxicology 2006;25(1):17-23. R825702 (Final)
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  • Journal Article Allen CB. An automated system for exposure of cultured cells and other materials to ozone. Inhalation Toxicology 2003;15(10):1039-1052. R825702 (Final)
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  • Journal Article Allen MJ, Harbeck R, Smith B, Voelker DR, Mason RJ. Binding of rat and human surfactant proteins A and D to Aspergillus fumigatus conidia. Infection and Immunity 1999;67(9):4563-4569. R825702 (Final)
    R825702C001 (Final)
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  • Journal Article Allen MJ, Voelker DR, Mason RJ. Interactions of surfactant proteins A and D with Saccharomyces cerevisiae and Aspergillus fumigatus. Infection and Immunity 2001;69(4):2037-2044. R825702 (Final)
    R825702C001 (Final)
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  • Journal Article Allen MJ, Laederach A, Reilly PJ, Mason RJ. Polysaccharide recognition by surfactant protein D: novel interactions of a C-type lectin with nonterminal glucosyl residues. Biochemistry 2001;40(26):7789-7798. R825702 (Final)
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  • Journal Article Allen MJ, Laederach A, Reilly PJ, Mason RJ, Voelker DR. Arg343 in human surfactant protein D governs discrimination between glucose and N-acetylglucosamine ligands. Glycobiology 2004;14(8):693-700. R825702 (Final)
    R825702C001 (Final)
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  • Journal Article Bin L-H, Nielson LD, Liu X, Mason RJ, Shu H-B. Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. The Journal of Immunology 2003;171(2):924-930. R825702 (Final)
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  • Journal Article Born WK, Lahn M, Takeda K, Kanehiro A, O'Brien RL, Gelfand EW. Role of γδ T cells in protecting normal airway function. Respiratory Research 2000;1(3):151-158. R825702 (Final)
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  • Journal Article Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM. Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation. American Journal of Respiratory and Critical Care Medicine 2007;176(1):10-19. R825702 (Final)
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  • Journal Article Cui Z-H, Joetham A, Aydintug MK, Hahn Y-S, Born WK, Gelfand EW. Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on γδ T cells. American Journal of Respiratory and Critical Care Medicine 2003;168(11):1324-1332. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Dakhama A, Kanehiro A, Makela MJ, Loader JE, Larsen GL, Gelfand EW. Regulation of airway hyperresponsiveness by calcitonin gene-related peptide in allergen sensitized and challenged mice. American Journal of Respiratory and Critical Care Medicine 2002;165(8):1137-1144. R825702 (Final)
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  • Journal Article Dakhama A, Kraft M, Martin RJ, Gelfand EW. Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-β1 in airway epithelial cells by Mycoplasma pneumoniae. American Journal of Respiratory Cell and Molecular Biology 2003;29(3):344-351. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Dakhama A, Larsen GL, Gelfand EW. Calcitonin gene-related peptide: role in airway homeostasis. Current Opinion in Pharmacology 2004;4(3):215-220. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Dakhama A, Park J-W, Taube C, Chayama K, Balhorn A, Joetham A, Wei X-D, Fan R-H, Swasey C, Miyahara N, Kodama T, Alvarez A, Takeda K, Gelfand EW. The role of virus-specific immunoglobulin E in airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2004;170(9):952-959. R825702 (Final)
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  • Journal Article Dakhama A, Park J-W, Taube C, El Gazzar M, Kodama T, Miyahara N, Takeda K, Kanehiro A, Balhorn A, Joetham A, Loader JE, Larsen GL, Gelfand EW. Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection. American Journal of Physiology-Lung Cellular and Molecular Physiology 2005;288(4):L761-L770. R825702 (Final)
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  • Journal Article Dakhama A, Park J-W, Taube C, Joetham A, Balhorn A, Miyahara N, Takeda K, Gelfand EW. The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus Is critically dependent on the age at first infection and IL-13 production. The Journal of Immunology 2005;175(3):1876-1883. R825702 (Final)
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  • Journal Article Fontenot AP, Falta MT, Freed BM, Newman LS, Kotzin BL. Identification of pathogenic T cells in patients with beryllium-induced lung disease. The Journal of Immunology 1999;163(2):1019-1026. R825702 (Final)
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  • Journal Article Fontenot AP, Torres M, Marshall WH, Newman LS, Kotzin BL. Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12717-12722. R825702 (Final)
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  • Journal Article Fujita M, Shannon JM, Irvin CG, Fagan KA, Cool C, Augustin A, Mason RJ. Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;280(1):L39-L49. R825702 (Final)
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  • Journal Article Fujita M, Shannon JM, Ouchi H, Voelker DR, Nakanishi Y, Mason RJ. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Cytokine 2005;31(1):25-33. R825702 (Final)
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  • Journal Article Gelfand EW, Joetham A, Cui Z-H, Balhorn A, Takeda K, Taube C, Dakhama A. Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization. Journal of Immunology 2004;173(2):1298-1306. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Gelfand EW, Dakhama A. CD8+ T lymphocytes and leukotriene B4: novel interations in the persistence and progression of asthma. Journal of Allergy and Clinical Immunology 2006;117(3):577-582. R825702 (Final)
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  • Journal Article Gelfand EW. Pediatric asthma: a different disease. Proceedings of the American Thoracic Society 2009;6(3):278-282. R825702 (Final)
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  • Journal Article Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, Irvin CG, Lee JJ, Kikutani H, Conrad D, Gelfand EW. CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2000;161(3):952-960. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Hahn Y-S, Taube C, Jin N, Sharp L, Wands JM, Aydintug MK, Lahn M, Huber SA, O'Brien RL, Gelfand EW, Born WK. Different potentials of γδT cell subsets in regulating airway responsiveness: Vγ1+ cells, but not Vγ4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation. The Journal of Immunology 2004;172(5):2894-2902. R825702 (Final)
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  • Journal Article Hamada K, Goldsmith C-A, Suzaki Y, Goldman A, Kobzik L. Airway hyperresponsiveness caused by aerosol exposure to residual oil fly ash leachate in mice. Journal of Toxicology and Environmental Health-Part A 2002;65(18):1351-1365. R825702 (Final)
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    R827353C014 (Final)
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  • Journal Article Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. American Journal of Respiratory Cell and Molecular Biology 2000;23(3):327-334. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Hirano A, Kanehiro A, Ono K, Ito W, Yoshida A, Okada C, Nakashima H, Tanimoto Y, Kataoka M, Gelfand EW, Tanimoto M. Pirfenidone modulates airway responsiveness, inflammation, and remodeling after repeated challenge. American Journal of Respiratory Cell and Molecular Biology 2006;35(3):366-377. R825702 (Final)
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  • Journal Article Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS. Toll-IL-1 receptor domain-containing adaptor protein Is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. The Journal of Immunology 2005;175(11):7484-7495. R825702 (Final)
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  • Journal Article Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS. Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium. American Journal of Respiratory Cell and Molecular Biology 2005;32(6):531-539. R825702 (Final)
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  • Journal Article Jin N, Taube C, Sharp L, Hahn Y-S, Yin X, Wands JM, Roark CL, O'Brien RL, Gelfand EW, Born WK. Mismatched antigen prepares γδ T cells for suppression of airway hyperresponsiveness. The Journal of Immunology 2005;174(5):2671-2679. R825702 (Final)
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  • Journal Article Jin N, Miyahara N, Roark CL, French JD, Aydintug MK, Matsuda JL, Gapin L, O'Brien RL, Gelfand EW, Born WK. Airway hyperresponsiveness through synergy of γδ T cells and NKT cells. The Journal of Immunology 2007;179(5):2961-2968. R825702 (Final)
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  • Journal Article Joetham A, Takeda K, Taube C, Miyahara N, Kanehiro A, Dakhama A, Gelfand EW. Airway hyperresponsiveness in the absence of CD4+ T cells after primary but not secondary challenge. American Journal of Respiratory Cell and Molecular Biology 2005;33(1):89-96. R825702 (Final)
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  • Journal Article Joetham A, Takada K, Taube C, Miyahara N, Matsubara S, Koya T, Rha YH, Dakhama A, Gelfand EW. Naturally occurring lung CD4+CD25+ T cell regulation of airway allergic responses depends on IL-10 induction of TGF-β. The Journal of Immunology 2007;178(3):1433-1442. R825702 (Final)
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  • Journal Article Joetham A, Takeda K, Miyahara N, Matsubara S, Ohnishi H, Koya T, Dakhama A, Gelfand EW. Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction. Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15057-15062. R825702 (Final)
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  • Journal Article Joetham A, Matsubara S, Okamoto M, Takeda K, Miyahara N, Dakhama A, Gelfand EW. Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses. The Journal of Immunology 2008;180(11):7117-7124. R825702 (Final)
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  • Journal Article Joetham A, Takeda K, Okamoto M, Taube C, Matsuda H, Dakhama A, Gelfand EW. Antigen specificity is not required for modulation of lung allergic responses by naturally occurring regulatory T cells. The Journal of Immunology 2009;183(3):1821-1827. R825702 (Final)
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  • Journal Article Kanehiro A, Takeda K, Joetham A, Tomkinson A, Ikemura T, Irvin CG, Gelfand EW. Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice. American Journal of Respiratory and Critical Care Medicine 2000;162(3):1132-1139. R825702 (Final)
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  • Journal Article Kanehiro A, Lahn M, Makela MJ, Dakhama A, Fujita M, Joetham A, Mason RJ, Born W, Gelfand EW. Tumor necrosis factor-α negatively regulates airway hyperresponsiveness through γδ T cells. American Journal of Respiratory and Critical Care Medicine 2001;164(12):2229-2238. R825702 (Final)
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  • Journal Article Kanehiro A, Ikemura T, Makela MJ, Lahn M, Joetham A, Dakhama A, Gelfand EW. Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. American Journal of Respiratory and Critical Care Medicine 2001;163(1):173-184. R825702 (Final)
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  • Journal Article Kanehiro A, Lahn M, Makela MJ, Dakhama A, Joetham A, Rha Y-H, Born W, Gelfand EW. Requirement for the p75 TNF-α receptor 2 in the regulation of airway hyperresponsiveness by γδ T cells. Journal of Immunology 2002;169(8):4190-4197. R825702 (Final)
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  • Journal Article Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW. Critical role of the Fc receptor γ-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. The Journal of Immunology 2007;178(1):480-488. R825702 (Final)
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  • Journal Article Kodama T, Kuribayashi K, Nakamura H, Fujita M, Fujita T, Takeda K, Dakhama A, Gelfand EW, Matsuyama T, Kitada O. Role of interleukin-12 in the regulation of CD4+ T cell apoptosis in a mouse model of asthma. Clinical and Experimental Immunology 2003;131(2):199-205. R825702 (Final)
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  • Journal Article Koya T, Takeda K, Kodama T, Miyahara N, Matsubara S, Balhorn A, Joetham A, Dakhama A, Gelfand EW. RANTES (CCL5) regulates airway responsiveness after repeated allergen challenge. American Journal of Respiratory Cell and Molecular Biology 2006;35(2):147-154. R825702 (Final)
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  • Journal Article Koya T, Kodama T, Takeda K, Miyahara N, Yang ES, Taube C, Joetham A, Park JW, Dakhama A, Gelfand EW. Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure. American Journal of Respiratory and Critical Care Medicine 2006;173(1):42-55. R825702 (Final)
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  • Journal Article Koya T, Matsuda JL, Takeda K, Matsubara S, Miyahara N, Balhorn A, Dakhama A, Gelfand EW. IL-10-treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice. The Journal of Allergy and Clinical Immunology 2007;119(5):1241-1250. R825702 (Final)
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  • Journal Article Koya T, Miyahara N, Takeda K, Matsubara S, Matsuda H, Swasey C, Balhorn A, Dakhama A, Gelfand EW. CD8+ T cell-mediated airway hyperresponsiveness and inflammation is dependent on CD4+IL-4+ T cells. The Journal of Immunology 2007;179(5):2787-2796. R825702 (Final)
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  • Journal Article Kumarathasan P, Blais E, Goegan P, Yagminas A, Guenette J, Adamson IY, Crapo JD, Mason RJ, Vincent R. 90-day repeated inhalation exposure of surfactant protein-C/tumor necrosis factor-α (SP-C/TNF-α) transgenic mice to air pollutants. International Journal of Toxicology 2005;24(1):59-67. R825702 (Final)
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  • Journal Article Lahn M, Kanehiro A, Takeda K, Terry J, Hahn Y-S, Aydintug MK, Konowal A, Ikuta K, O'Brien RL, Gelfand EW, Born WK. MHC class I-dependent Vγ4+ pulmonary T cells regulate αβT cell-independent airway responsiveness. Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8850-8855. R825702 (Final)
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  • Journal Article Larsen GL, White CW, Takeda K, Loader JE, Nguyen DDH, Joetham A, Groner Y, Gelfand EW. Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control. American Journal of Physiology-Lung Cellular and Molecular Physiology 2000;279(2):L350-L359. R825702 (Final)
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  • Journal Article Lee NA, Gelfand EW, Lee JJ. Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? The Journal of Allergy and Clinical Immunology 2001;107(6):945-957. R825702 (Final)
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  • Journal Article Lee Y-M, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A. IFN-γ production during initial infection determines the outcome of reinfection with respiratory syncytial virus. American Journal of Respiratory and Critical Care Medicine 2008;177(2):208-218. R825702 (Final)
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  • Journal Article Lively TN, Kossen K, Balhorn A, Koya T, Zinnen S, Takeda K, Lucas JJ, Polisky B, Richards IM, Gelfand EW. Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice. The Journal of Allergy and Clinical Immunology 2008;121(1):88-94. R825702 (Final)
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  • Journal Article Maier LA, Raynolds MV, Young DA, Barker EA, Newman LS. Angiotensin-1 converting enzyme polymorphisms in chronic beryllium disease. American Journal of Respiratory and Critical Care Medicine 1999;159(4):1342-1350. R825702 (Final)
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  • Journal Article Makela MJ, Kanehiro A, Borish L, Dakhama A, Loader J, Joetham A, Xing Z, Jordana M, Larsen GL, Gelfand EW. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):6007-6012. R825702 (Final)
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  • Journal Article Makela MJ, Kanehiro A, Dakhama A, Borish L, Joetham A, Tripp R, Anderson L, Gelfand EW. The failure of interleukin-10-deficient mice to develop airway hyperresponsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. American Journal of Respiratory and Critical Care Medicine 2002;165(6):824-831. R825702 (Final)
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  • Journal Article Makela MJ, Tripp R, Dakhama A, Park J-W, Ikemura T, Joetham A, Waris M, Anderson LJ, Gelfand EW. Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness. The Journal of Allergy and Clinical Immunology 2003;112(5):861-869. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Manzer R, Wang J, Nishina K, McConville G, Mason RJ. Alveolar epithelial cells secrete chemokines in response to IL-1β and lipopolysaccharide but not to ozone. American Journal of Respiratory Cell and Molecular Biology 2006;34(2):158-166. R825702 (Final)
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  • Journal Article Manzer R, Dinarello CA, McConville G, Mason RJ. Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha. American Journal of Respiratory Cell and Molecular Biology 2008;38(3):318-323. R825702 (Final)
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  • Journal Article Mason RJ. Biology of alveolar type II cells. Respirology 2006;11(Suppl 1):S12-S15. R825702 (Final)
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  • Journal Article Matsubara S, Koya T, Takeda K, Joetham A, Miyahara N, Pine P, Masuda ES, Swasey CH, Gelfand EW. Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. American Journal of Respiratory Cell and Molecular Biology 2006;34(4):426-433. R825702 (Final)
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  • Journal Article Matsubara S, Li G, Takeda K, Loader JE, Pine P, Masuda ES, Miyahara N, Miyahara S, Lucas JJ, Dakhama A, Gelfand EW. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2006;173(1):56-63. R825702 (Final)
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  • Journal Article Matsubara S, Takeda K, Kodama T, Joetham A, Miyahara N, Koya T, Swasey CH, Okamoto M, Dakhama A, Gelfand EW. IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-γ, and natural killer cells. American Journal of Respiratory Cell and Molecular Biology 2007;36(3):324-332. R825702 (Final)
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  • Journal Article Matsubara S, Swasey CH, Loader JE, Dakhama A, Joetham A, Ohnishi H, Balhorn A, Miyahara N, Takeda K, Gelfand EW. Estrogen determines sex differences in airway responsiveness after allergen exposure. American Journal of Respiratory Cell and Molecular Biology 2008;38(5):501-508. R825702 (Final)
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  • Journal Article Miyahara N, Swanson BJ, Takeda K, Taube C, Miyahara S, Kodama T, Dakhama A, Ott VL, Gelfand EW. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nature Medicine 2004;10(8):865-869. R825702 (Final)
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  • Journal Article Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park J-W, Miyahara S, Balhorn A, Dakhama A, Gelfand EW. Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. The Journal of Immunology 2004;172(4):2549-2558. R825702 (Final)
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  • Journal Article Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T, Matsubara S, Dakhama A, Tager AM, Luster AD, Gelfand EW. Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness. The Journal of Immunology 2005;174(8):4979-4984. R825702 (Final)
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  • Journal Article Miyahara N, Takeda K, Miyahara S, Matsubara S, Koya T, Joetham A, Krishnan E, Dakhama A, Haribabu B, Gelfand EW. Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2005;172(2):161-167. R825702 (Final)
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  • Journal Article Nishina K, Zhang F, Nielsen LD, Edeen K, Wang J, Mason RJ. Expression of CINC-2β is related to the state of differentiation of alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2005;33(5):505-512. R825702 (Final)
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  • Journal Article Ohnishi H, Miyahara N, Dakhama A, Takeda K, Mathis S, Haribabu B, Gelfand EW. Corticosteroids enhance CD8+ T cell-mediated airway hyperresponsiveness and allergic inflammation by upregulating leukotriene B4 receptor 1. The Journal of Allergy and Clinical Immunology 2008;121(4):864-871. R825702 (Final)
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  • Journal Article Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Swanson BJ, Yasutomo K, Dakhama A, Gelfand EW. Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation. The Journal of Experimental Medicine 2008;205(5):1087-1097. R825702 (Final)
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  • Journal Article Pacheco KA, Tarkowski M, Sterritt C, Negri J, Rosenwasser LJ, Borish L. The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-β and IL-1β. Clinical and Experimental Immunology 2001;126(3):374-383. R825702 (Final)
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  • Journal Article Pan T, Nielsen LD, Allen MJ, Shannon KM, Shannon JM, Selman M, Mason RJ. Serum SP-D is a marker of lung injury in rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;282(4):L824-L832. R825702 (Final)
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  • Journal Article Panayiotidis MI, Stabler SP, Allen RH, Ahmad A, White CW. Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells. Chemico-Biological Interactions 2004;147(1):87-97. R825702 (Final)
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  • Journal Article Panayiotidis MI, Rancourt RC, Allen CB, Riddle SR, Schneider BK, Ahmad S, White CW. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antioxidants & Redox Signaling 2004;6(1):129-136. R825702 (Final)
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  • Journal Article Panayiotidis MI, Stabler SP, Ahmad A, Pappa A, Legros Jr LH, Hernandez-Saavedra D, Schneider BK, Allen RH, Vasiliou V, McCord JM, Kotb M, White CW. Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia. Free Radical Biology and Medicine 2006;40(2):348-358. R825702 (Final)
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  • Journal Article Panayiotidis MI, Stabler SP, Allen RH, Pappa A, White CW. Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2009;674(1-2):23-30. R825702 (Final)
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  • Journal Article Park J-W, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Schultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 2004;169(6):726-732. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW. Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen. The Journal of Allergy and Clinical Immunology 2003;112(6):1078-1087. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Park J-W, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim S-H, Dinarello CA, Gelfand EW. Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. American Journal of Respiratory Cell and Molecular Biology 2004;30(6):830-836. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Pulfer MK, Taube C, Gelfand E, Murphy RC. Ozone exposure in vivo and formation of biologically active oxysterols in the lung. Journal of Pharmacology and Experimental Therapeutics 2005;312(1):256-264. R825702 (Final)
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  • Journal Article Rabinovitch N, Zhang L, Murphy JR, Vedal S, Dutton SJ, Gelfand EW. Effects of wintertime ambient air pollutants on asthma exacerbations in urban minority children with moderate to severe disease. The Journal of Allergy and Clinical Immunology 2004;114(5):1131-1137. R825702 (Final)
    R825702C013 (Final)
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  • Journal Article Rabinovitch N, Liu AH, Zhang L, Rodes CE, Foarde K, Dutton SJ, Murphy JR, Gelfand EW. Importance of the personal endotoxin cloud in school-age children with asthma. The Journal of Allergy and Clinical Immunology 2005;116(5):1053-1057. R825702 (Final)
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  • Journal Article Rabinovitch N, Strand M, Gelfand EW. Particulate levels are associated with early asthma worsening in children with persistent disease. American Journal of Respiratory and Critical Care Medicine 2006;173(10):1098-1105. R825702 (Final)
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  • Journal Article Rabinovitch N, Liu AH, Zhang L, Foarde K, Rodes CE, Gelfand EW. Increased personal respirable endotoxin exposure with furry pets. Allergy 2006;61(5):650-651. R825702 (Final)
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  • Journal Article Rabinovitch N, Zhang L, Gelfand EW. Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction. The Journal of Allergy and Clinical Immunology 2006;118(3):635-640. R825702 (Final)
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  • Journal Article Rha Y-H, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born WK, Dakhama A, Gelfand EW. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. Journal of Immunology 2002;169(9):5300-5307. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Silkoff PE, Zhang L, Dutton S, Langmack EL, Vedal S, Murphy J, Make B. Winter air pollution and disease parameters in advanced chronic obstructive pulmonary disease panels residing in Denver, Colorado. The Journal of Allergy and Clinical Immunology 2005;115(2):337-344. R825702 (Final)
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  • Journal Article Strand M, Vedal S, Rodes C, Dutton SJ, Gelfand EW, Rabinovitch N. Estimating effects of ambient PM2.5 exposure on health using PM2.5 component measurements and regression calibration. Journal of Exposure Science and Environmental Epidemiology 2006;16(1):30-38. R825702 (Final)
    R825702C013 (Final)
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  • Journal Article Strand M, Hopke PK, Zhao W, Vedal S, Gelfand E, Rabinovitch N. A study of health effect estimates using competing methods to model personal exposures to ambient PM2.5 modeling personal exposures to PM2.5. Journal of Exposure Science and Environmental Epidemiology 2007;17(6):549-558. R825702 (Final)
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  • Journal Article Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL. MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. Journal of Biological Chemistry 2001;276(7):5093-5100. R825702 (Final)
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  • Journal Article Takeda K, Okamoto M, de Langhe S, Dill E, Armstrong M, Reisdorf N, Irwin D, Koster M, Wilder J, Stenmark KR, West J, Klemm D, Gelfand EW, Nozik-Grayck E, Majka SM. Peroxisome proliferator-activated receptor-γ agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental neonatal chronic lung disease. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology 2009;292(7):1045-1061. R825702 (Final)
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  • Journal Article Taube C, Duez C, Cui Z-H, Takeda K, Rha YH, Park J-W, Balhorn A, Donaldson DD, Dakhama A, Gelfand EW. The role of IL-13 in established allergic airway disease. The Journal of Immunology 2002;169(11):6482-6489. R825702 (Final)
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  • Journal Article Taube C, Dakhama A, Rha Y-H, Takeda K, Joetham A, Park J-W, Balhorn A, Takai T, Poch KR, Nick JA, Gelfand EW. Transient neutrophil infiltration after allergen challenge is dependent on specific antibodies and FcγIII receptors. The Journal of Immunology 2003;170(8):4301-4309. R825702 (Final)
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  • Journal Article Taube C, Rha Y-H, Takeda K, Park J-W, Joetham A, Balhorn A, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Inhibition of complement activation decreases airway inflammation and hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2003;168(11):1333-1341. R825702 (Final)
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  • Journal Article Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha Y-H, Park J-W, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology 2004;30(6):837-843. R825702 (Final)
    R825702C012 (Final)
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  • Journal Article Taube C, Wei X, Swasey CH, Joetham A, Zarini S, Lively T, Takeda K, Loader J, Miyahara N, Kodama T, Shultz LD, Donaldson DD, Hamelmann EH, Dakhama A, Gelfand EW. Mast cells, FcεRI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. The Journal of Immunology 2004;172(10):6398-6406. R825702 (Final)
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  • Journal Article Taube C, Miyahara N, Ott V, Swanson B, Takeda K, Loader J, Shultz LD, Tager AM, Luster AD, Dakhama A, Gelfand EW. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. The Journal of Immunology 2006;176(5):3157-3164. R825702 (Final)
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  • Journal Article Taube C, Thurman JM, Takeda K, Joetham A, Miyahara N, Carroll MC, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation. Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8084-8089. R825702 (Final)
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  • Journal Article Taylor MD, Van Dyke K, Bowman LL, Miles PR, Hubbs AF, Mason RJ, Shannon K, Reasor MJ. A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity. Toxicology and Applied Pharmacology 2000;167(3):182-190. R825702 (Final)
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  • Journal Article Tomkinson A, Cieslewicz G, Duez C, Larson KA, Lee JJ, Gelfand EW. Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice. American Journal of Respiratory and Critical Care Medicine 2001;163(3):721-730. R825702 (Final)
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  • Journal Article Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt M-C, Gundel R, Gelfand EW. A murine IL-4 receptor antagonist that inhibits IL-4-and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. Journal of Immunology 2001;166(9):5792-5800. R825702 (Final)
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  • Journal Article Uhlson C, Harrison K, Allen CB, Ahmad S, White CW, Murphy RC. Oxidized phospholipids derived from ozone-treated lung surfactant extract reduce macrophage and epithelial cell viability. Chemical Research in Toxicology 2002;15(7):896-906. R825702 (Final)
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  • Journal Article Wands JM, Roark CL, Aydintug MK, Jin N, Hahn Y-S, Cook L, Yin X, Dal Porto J, Lahn M, Hyde DM, Gelfand EW, Mason RJ, O'Brien RL, Born WK. Distribution and leukocyte contacts of γδ T cells in the lung. Journal of Leukocyte Biology 2005;78(5):1086-1096. R825702 (Final)
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  • Journal Article Wang J, Wang S, Manzer R, McConville G, Mason RJ. Ozone induces oxidative stress in rat alveolar type II and type I-like cells. Free Radical Biology & Medicine 2006;40(11):1914-1928. R825702 (Final)
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  • Journal Article Zhang F, Pao W, Umphress SM, Jakowlew SB, Meyer AM, Dwyer-Nield LD, Nielsen LD, Takeda K, Gelfand EW, Fisher JH, Zhang L, Malkinson AM, Mason RJ. Serum levels of surfactant protein D are increased in mice with lung tumors. Cancer Research 2003;63(18):5889-5894. R825702 (Final)
    R825702C001 (Final)
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  • Journal Article Zhao W, Hopke PK, Gelfand EW, Rabinovitch N. Use of an expanded receptor model for personal exposure analysis in schoolchildren with asthma. Atmospheric Environment 2007;41(19):4084-4096. R825702 (Final)
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  • Supplemental Keywords:

    Health, Scientific Discipline, Air, air toxics, Health Risk Assessment, Epidemiology, Risk Assessments, Disease & Cumulative Effects, Biochemistry, Atmospheric Sciences, Biology, health effects, air pollutants, lung disease, acute lung injury, lung epithelial cells, airway disease, human exposure, susceptibility, environmental toxicant, animal studies, human health risk, genetic susceptibility, occupational exposure

    Progress and Final Reports:

  • 1998
  • 1999
  • 2000
  • 2001
  • 2002
  • 2003
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R825702C001 SP-A and SP-D in Environmental Lung Disease
    R825702C003 Adaptation to Nitrogen Dioxide: Role of Altered Glycolytic Pathway Enzyme Expression and NF-κB-Dependent Cellular Defenses Against Apoptosis
    R825702C005 Inhalation of Particulate Matter Alters the Allergic Airway Response to Inhaled Allergen
    R825702C006 Particle-Induced Lung Inflammation and Extracellular EC-SOD
    R825702C007 Indoor-Outdoor Relationships of Airborne Particle Count and Endotoxin Concentrations
    R825702C008 The Role of Mitochondrial DNA Mutations in Oxidant-Mediated Lung Injury
    R825702C009 Immunopathogenesis of Hypersensitivity Pneumonitis in the Mouse
    R825702C010 Activation of Natural T Lymphocytes by Diesel Exhaust Particulates Leads to Their Production of Interleukin-4 and TH2 Lymphocyte Differentiation to Allergen
    R825702C011 Latex Antigen Levels During Powdered and Powderless Glove Use
    R825702C012 Adjuvant Effects of Ozone in a Model of Allergen-Induced Airway Inflammation and Hyperresponsiveness
    R825702C013 Acute Exposure to Particulate Air Pollution in Childhood Asthma
    R825702C014 Mechanisms of Ozone Toxicity to the Lung