Temporal Models for Biomarker Based Exposure Inference

EPA Grant Number: U915829
Title: Temporal Models for Biomarker Based Exposure Inference
Investigators: Bartell, Scott M.
Institution: University of California - Davis
EPA Project Officer: Michaud, Jayne
Project Period: September 1, 2000 through September 1, 2003
Project Amount: $82,484
RFA: STAR Graduate Fellowships (2000) RFA Text |  Recipients Lists
Research Category: Academic Fellowships , Fellowship - Molecular Biology/Genetics , Biology/Life Sciences


The objective of the research project is to develop appropriate toxicokinetic/toxicodynamic based statistical methods for exposure inferences based on biomarker measurements.


In many toxicokinetic models, exposures may be reasonably treated as discrete events occurring daily with randomly distributed magnitudes. Biomarker measurements appropriate for this model, such as blood mercury concentrations, can be written as time-weighted linear combinations of all prior exposure events. Classic mathematical statistics methods can then be used to develop equations describing the statistical properties of the biomarker measurements and their relationship to exposure history.

Expected Results:

By using classic mathematical statistics methods, equations can be developed to describe the statistical properties of biomarker measurements.

Supplemental Keywords:

human health, risk, mercury, methodology, population, variability., Health, Scientific Discipline, Toxics, National Recommended Water Quality, Applied Math & Statistics, Toxicology, Health Risk Assessment, HAPS, Risk Assessments, 33/50, risk, toxicokinetic, mercury, human exposure, temporal models, mercury & mercury compounds, Mercury Compounds, biomarker based exposure inference, human health risk, statistical methods, population, biomarker, toxicokinetic models

Progress and Final Reports:

  • 2001
  • 2002
  • Final