Personal PM Exposure AssessmentEPA Grant Number: R827355C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Personal PM Exposure Assessment
Investigators: Liu, Sally , Claiborn, Candis , Larson, Timothy V. , Gundel, Lara
Current Investigators: Liu, Sally , Claiborn, Candis , Koenig, Jane Q. , Larson, Timothy V. , Simpson, Chris , Kalman, Dave , Allen, Ryan
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air
Objective:Recent findings of the association between daily mortality and ambient daily PM10 and PM2.5 concentrations well below the 24-h National Ambient Air Quality Standards (NAAQS) for PM10 has prompted the new NAAQS for PM2.5. However, whether the population exposure to PM is related to the concentration measured at an outdoor site remains unanswered. This study was funded to provide information to resolve this crucial issue. The study subjects are patients with chronic respiratory disease and cardiovascular complications residing in the metropolitan Seattle area. Year-round personal, biological, indoor, and outdoor PM measurements, as well as other co-varying air pollutants will be taken from 60 patients. The objectives of this study are to: (1) determine the strength of the relationship of the particle exposures of high-risk subpopulations to the concentrations measured by a central monitoring station; (2) characterize the key factors influencing this relationship; and (3) link exposure data with health outcomes to focus exposure modeling on unbiased estimation of health effects. This study is being conducted in the Seattle Metropolitan area. Personal, biological (urine and breath), indoor, and outdoor PM10, PM2.5, CO, SO2, and NO2 measurements are taken throughout the year using the Harvard/Marple personal exposure monitors for PM, passive monitors for CO, SO2, and NO2, and nephelometers for continuous PM1. The biomarker technique recently developed at the University of Washington serves as a unique tracer for ambient PM exposures. At any given time, 5 patients are monitored simultaneously and 30 patients are to be monitored in high and medium-low wood smoke seasons each year. Subjects include 30 chronic obstructive pulmonary disease (COPD) and 30 cardiovascular patients living in either group or private homes, as well as 24 healthy subjects monitored as controls. We also collect information on personal time-location-activity-symptom, events that occur in residences that may generate or reduce PM, building characteristics, continuous CO2 concentrations, temperature, and relative humidity. Furthermore, the exposure data are supplemented with peak expiratory flow rate, pulse rate, oxygen saturation, blood pressure, and electrocardiogram measurements from all subjects.
Publications and Presentations:Publications have been submitted on this subproject: View all 65 publications for this subproject | View all 209 publications for this center
Journal Articles:Journal Articles have been submitted on this subproject: View all 25 journal articles for this subproject | View all 109 journal articles for this center
Supplemental Keywords:ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility., RFA, Health, Scientific Discipline, Air, Geographic Area, particulate matter, air toxics, Environmental Chemistry, Health Risk Assessment, Epidemiology, State, Northwest, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, genetic susceptability, indoor air, Atmospheric Sciences, ambient aerosol, ambient air quality, asthma, biostatistics, health effects, particulates, PM10, sensitive populations, air pollutants, cardiopulmonary responses, fine particles, health risks, human health effects, morbidity, PM 2.5, toxicology, stratospheric ozone, exposure and effects, ambient air, exposure, hazardous air pollutants, animal model, combustion emissions, air pollution, children, Human Health Risk Assessment, particle exposure, cardiopulmonary response, human exposure, inhalation, PAHs, atmospheric aerosols, ambient particle health effects, mortality studies, hydrocarbons, human susceptibility, Seattle, Washington, incineration, indoor air quality, mortality, California (CA), allergens, aerosols, air quality, atmospheric chemistry, cardiovascular disease, exposure assessment, human health risk
Progress and Final Reports:
Main Center Abstract and Reports:R827355 Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
R827355C002 Health Effects
R827355C003 Personal PM Exposure Assessment
R827355C004 Characterization of Fine Particulate Matter
R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
R827355C006 Toxicology Project -- Controlled Exposure Facility
R827355C007 Health Effects Research Core
R827355C008 Exposure Core
R827355C009 Statistics and Data Core
R827355C010 Biomarker Core
R827355C011 Oxidation Stress Makers