2002 Progress Report: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures

EPA Grant Number: R827353C010
Subproject: this is subproject number 010 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
Investigators: Speizer, Frank E.
Current Investigators: Speizer, Frank E. , Park, S.
Institution: Harvard University
Current Institution: Harvard T.H. Chan School of Public Health , Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2001 through May 31, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air


The main objective of this research project is to investigate associations of selected inflammatory and blood clotting parameters in free living humans with particle and criteria gas exposures.

Progress Summary:

This project is in collaboration with the Boston Veterans Hospital who currently is conducting the Normative Aging Study (NAS). During the first 3 years the VA Hospital has been collecting data. Measurements of approximately 650 individuals out of 1,200 participants have been completed. Statistical analysis, relationships to ambient pollution levels, and geographical relationships have just commenced. A plan for the data analysis was presented during the 2003 Scientific Advisory Committee meeting last March.

A new panel study was conducted last year in St. Louis, MO. Forty-four elderly individuals from four senior independent living facilities were enrolled for participation in the study. To evaluate the effect of traffic-related air pollution on cardiovascular health, individuals participated in a series of four separate day-trips from their suburban residences to activities in downtown St. Louis. Each day trip included two one-hour bus rides on a shuttle bus. In order to characterize gaseous and particulate exposures before, during, and after the bus trips, a number of continuous samplers were employed. These samplers were installed on two roll-around carts and in the rear of the shuttle bus. Continuous measurements of cardiac function were also collected during each day of participation using Holter monitors. In addition, samples of exhaled nitric oxide, blood pressure, blood oxygen, and blood samples were collected from participants before and after the trips. All data have been processed and data analysis has just begun.


Lippman M, Frampton M, Schwartz J, Dockery DW, Schlesinger R, Koutrakis P, Froines J. The EPA's Particulate Matter (PM) Health Effects Research Centers Program: a mid-course (2 1/2 year) report of status, progress, and plans. Environmental Health Perspectives (in press, 2003).

Future Activities:

We will complete the data analysis and prepare manuscripts for publication.

Journal Articles:

No journal articles submitted with this report: View all 6 publications for this subproject

Supplemental Keywords:

air pollution, air pollutants, particulates, particulate matter, PM, fine particulates, PM2.5, blood viscosity, clotting parameters, heart rate, heart rate variability, criteria gas exposure, PM exposure, health effects, ambient pollution, ambient particles, Boston, Massachusetts, MA, St. Louis, Missouri, MO, elderly, susceptible populations, cardiac function, exhaled nitric oxide, blood pressure, blood oxygen., RFA, Health, Scientific Discipline, Air, Geographic Area, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, State, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Environmental Monitoring, Atmospheric Sciences, Molecular Biology/Genetics, Biology, Environmental Engineering, ambient air quality, health effects, interindividual variability, molecular epidemiology, monitoring, particle size, particulates, risk assessment, sensitive populations, cardiac arrhythmia, chemical exposure, atmospheric particulate matter, air pollutants, cardiopulmonary responses, health risks, human health effects, ambient air monitoring, exposure and effects, ambient air, ambient measurement methods, exposure, pulmonary disease, developmental effects, epidemelogy, respiratory disease, automotive emissions, air pollution, children, Human Health Risk Assessment, Massachusetts (MA), particle exposure, lung cancer, biological mechanism , cardiopulmonary response, chronic effects, human exposure, inhalation, pulmonary, particulate exposure, ambient particle health effects, blood viscosity, heart rate, elderly, inhaled, PM, human susceptibility, inhalation toxicology, gaseous co-polutants, cardiopulmonary, indoor air quality, inhaled particles, human health, cardiac ischemia, traffic related air pollution, air quality, cardiovascular disease, dosimetry, human health risk, metals, respiratory, genetic susceptibility, cardiopulmonery responses, toxics

Relevant Websites:

http://www.hsph.harvard.edu/epacenter/ Exit

Progress and Final Reports:

Original Abstract
  • 1999
  • 2000 Progress Report
  • 2001 Progress Report
  • 2003 Progress Report
  • 2004
  • Final Report

  • Main Center Abstract and Reports:

    R827353    EPA Harvard Center for Ambient Particle Health Effects

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
    R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
    R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
    R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
    R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
    R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
    R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
    R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
    R827353C009 Assessing Deposition of Ambient Particles in the Lung
    R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
    R827353C011 Studies of Oxidant Mechanisms
    R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
    R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
    R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
    R827353C015 Research Coordination Core
    R827353C016 Analytical and Facilities Core
    R827353C017 Technology Development and Transfer Core