Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures

EPA Grant Number: R827353C010
Subproject: this is subproject number 010 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
Investigators: Speizer, Frank E.
Current Investigators: Speizer, Frank E. , Park, S.
Institution: Harvard University
Current Institution: Harvard T.H. Chan School of Public Health , Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air


This project is one of three under Theme III: Biological Mechanisms and Dosimetry of our proposal. The main objective of this project is to investigate associations of selected inflammatory and blood clotting parameters in free living humans with particle and criteria gas exposures.

Theme III includes three projects which aim to identify the particulate and gaseous air pollutants responsible for increased cardiac vulnerability and to define the biological mechanisms that lead to this outcome. Projects IIIa and IIIb are both based on a dog model of coronary occlusion and controlled exposures to concentrated ambient particles. Project IIIa will use this model and technology to explore the role of particle size (coarse, fine, and ultra fine), particle composition (metals, ions, and carbon), and criteria gases (O3, NO2, CO, and SO2) on cardiac and respiratory health. Project IIIa will also use pharmacological intervention to explore biological mechanisms by which particles accelerate and increase sensitivity to the ischemic response, examining both autonomic nervous system and inflammatory mechanisms. Project IIIb will determine in-situ particle doses during the inhalation studies using online measurements of particle number and size in the inhaled and exhaled air. This will enable us to provide a better interpretation of the observed outcomes and to examine the role of particle composition, gaseous co-pollutants, and susceptibility on particle deposition. The third project, Project IIIc, is a human panel study, which will be performed concurrent with our animal inhalation projects. Project IIIc will investigate the effects of particle mass, composition, and gaseous co-pollutants on blood viscosity, other clotting parameters, and cardiac health of individuals living in the Boston Metropolitan area. Results from this project will be integrated with results from animal inhalation studies to improve our understanding of the role of particle composition and gaseous co-pollutants on cardiovascular health and of the biological mechanisms leading to the adverse effects.

Publications and Presentations:

Publications have been submitted on this subproject: View all 6 publications for this subprojectView all 200 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 6 journal articles for this subprojectView all 197 journal articles for this center

Supplemental Keywords:

particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring., RFA, Health, Scientific Discipline, Air, Geographic Area, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, State, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Environmental Monitoring, Atmospheric Sciences, Molecular Biology/Genetics, Biology, Environmental Engineering, ambient air quality, health effects, interindividual variability, molecular epidemiology, monitoring, particle size, particulates, risk assessment, sensitive populations, cardiac arrhythmia, chemical exposure, atmospheric particulate matter, air pollutants, cardiopulmonary responses, health risks, human health effects, ambient air monitoring, exposure and effects, ambient air, ambient measurement methods, exposure, pulmonary disease, developmental effects, epidemelogy, respiratory disease, automotive emissions, air pollution, children, Human Health Risk Assessment, Massachusetts (MA), particle exposure, lung cancer, biological mechanism , cardiopulmonary response, chronic effects, human exposure, inhalation, pulmonary, particulate exposure, ambient particle health effects, blood viscosity, heart rate, elderly, inhaled, PM, human susceptibility, inhalation toxicology, gaseous co-polutants, cardiopulmonary, indoor air quality, inhaled particles, human health, cardiac ischemia, traffic related air pollution, air quality, cardiovascular disease, dosimetry, human health risk, metals, respiratory, genetic susceptibility, cardiopulmonery responses, toxics

Progress and Final Reports:

  • 1999
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004
  • Final Report

  • Main Center Abstract and Reports:

    R827353    EPA Harvard Center for Ambient Particle Health Effects

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
    R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
    R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
    R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
    R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
    R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
    R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
    R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
    R827353C009 Assessing Deposition of Ambient Particles in the Lung
    R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
    R827353C011 Studies of Oxidant Mechanisms
    R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
    R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
    R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
    R827353C015 Research Coordination Core
    R827353C016 Analytical and Facilities Core
    R827353C017 Technology Development and Transfer Core