2002 Progress Report: Assessing Deposition of Ambient Particles in the Lung

EPA Grant Number: R827353C009
Subproject: this is subproject number 009 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Assessing Deposition of Ambient Particles in the Lung
Investigators: Tsuda, Akira
Current Investigators: Godleski, John J. , Tsuda, Akira
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2002 through May 31, 2003
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air


The main objective of this research project is to use in situ continuous respiratory and total deposition measurement to develop a new regional deposition model.

Progress Summary:

Original Center activities focused on the development of theoretical models used to predict PM deposition as a function of size (Tsuda, et al., 2002). Subsequently, a series of human ambient particle deposition studies were conducted. The total deposition fraction of fine and ultra-fine aerosols was measured in a group of six healthy adults exposed to Boston ambient particles. The deposition efficiency of particles ranging from 40 to 2,045 nm was determined using the average concentration of inhaled and exhaled particles measured during these cycles. Deposition efficiencies ranged between 7.3 ± 18.7 percent (for particles 168-195 nm) and 98.6 ± 28.1 percent (for particles 1545-2045 nm). Subjects exhibited similar deposition patterns with a minimum efficiency in the size range of 100-200 nm. Results from ANOVA and mixed model regression analyses, suggested that deposition efficiency varied with individual and particle size. Deposition efficiencies varied mostly among subjects for particles in the size range between 100 and 1,000 nm.


Lippman M, Frampton M, Schwartz J, Dockery DW, Schlesinger R, Koutrakis P, Froines J. The EPA's Particulate Matter (PM) Health Effects Research Centers Program: a mid-course (2 1/2 year) report of status, progress, and plans. Environmental Health Perspectives (in press, 2003).

Future Activities:

A manuscript has been submitted for publication (Montoya, et al., 2003). No additional deposition studies have been planned.

Journal Articles on this Report : 2 Displayed | Download in RIS Format

Other subproject views: All 4 publications 4 publications in selected types All 4 journal articles
Other center views: All 200 publications 198 publications in selected types All 197 journal articles
Type Citation Sub Project Document Sources
Journal Article Haber S, Yitzhak D, Tsuda A. Gravitational deposition in a rhythmically expanding and contracting alveolus. Journal of Applied Physiology 2003;95(2):657-671. R827353 (Final)
R827353C009 (2002)
R827353C009 (Final)
  • Abstract from PubMed
  • Full-text: JAP-Full Text PDF
  • Abstract: JAP-Abstract & Full Text HTML
  • Journal Article Henry FS, Butler JP, Tsuda A. Kinematically irreversible acinar flow:a departure from classical dispersive aerosol transport theories. Journal of Applied Physiology 2002;92(2):835-845. R827353 (Final)
    R827353C009 (2002)
    R827353C009 (Final)
  • Abstract from PubMed
  • Full-text: JAP-Full Text HTML
  • Abstract: JAP-Abstract
  • Other: JAP-Full Text PDF
  • Supplemental Keywords:

    ambient particles, air pollution, air pollutants, particulates, particulate matter, PM, fine particulates, PM2.5, lung deposition, ambient particle lung deposition, fine aerosols, ultrafine aerosols., RFA, Health, Scientific Discipline, Air, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Environmental Microbiology, genetic susceptability, indoor air, Molecular Biology/Genetics, Biology, ambient air quality, health effects, interindividual variability, molecular epidemiology, monitoring, particulates, risk assessment, sensitive populations, chemical exposure, air pollutants, cardiopulmonary responses, health risks, human health effects, indoor exposure, stratospheric ozone, ambient air monitoring, exposure and effects, ambient air, ambient measurement methods, exposure, pulmonary disease, developmental effects, epidemelogy, respiratory disease, COPD, air pollution, ambient monitoring, Human Health Risk Assessment, particle exposure, biological mechanism , cardiopulmonary response, human exposure, inhalation, pulmonary, particulate exposure, ambient particle health effects, heart rate, inhaled, PM, human susceptibility, inhalation toxicology, cardiopulmonary, indoor air quality, inhaled particles, human health, air quality, cardiovascular disease, dosimetry, human health risk, metals, respiratory, genetic susceptibility, toxics

    Relevant Websites:

    http://www.hsph.harvard.edu/epacenter/ Exit

    Progress and Final Reports:

    Original Abstract
  • 1999 Progress Report
  • 2000 Progress Report
  • 2001 Progress Report
  • 2003
  • 2004
  • Final Report

  • Main Center Abstract and Reports:

    R827353    EPA Harvard Center for Ambient Particle Health Effects

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
    R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
    R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
    R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
    R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
    R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
    R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
    R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
    R827353C009 Assessing Deposition of Ambient Particles in the Lung
    R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
    R827353C011 Studies of Oxidant Mechanisms
    R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
    R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
    R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
    R827353C015 Research Coordination Core
    R827353C016 Analytical and Facilities Core
    R827353C017 Technology Development and Transfer Core