Indoor-Outdoor Relationships of Airborne Particle Count and Endotoxin Concentrations

EPA Grant Number: R825702C007
Subproject: this is subproject number 007 , established and managed by the Center Director under grant R825702
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Environmental Lung Disease Center (National Jewish Medical and Research Center)
Center Director: Mason, Robert J.
Title: Indoor-Outdoor Relationships of Airborne Particle Count and Endotoxin Concentrations
Investigators: Fennelly, Kevin P.
Institution: National Jewish Medical and Research Center
EPA Project Officer: Chung, Serena
Project Period: February 16, 1998 through February 28, 2003 (Extended to February 28, 2004)
RFA: Environmental Lung Disease Center (National Jewish Medical and Research Center) (1998) RFA Text |  Recipients Lists
Research Category: Targeted Research

Objective:

Although there is consistent and coherent epidemiological evidence that particulate air pollution is associated with cardiopulmonary morbidity and mortality, the biological mechanisms underlying these findings are unknown. In order for airborne particles to produce disease, they must penetrate indoors where such individuals spend most of their time. We hypothesize that submicron particles penetrate indoors from outdoors considerably more than larger particles. We propose assessing indoor/outdoor ratios of particle count concentrations for submicron particles and for larger particles. We will assess the indoor environments of subjects with asthma enrolled in a recent panel study of the association between daily submicron particle counts and daily asthma symptoms, medication use, and physiological changes. We hypothesize that the subjects with the strongest associations between asthma indices and submicron particle counts are more likely to live in residences with the highest indoor/outdoor ratios. We suggest that airborne endotoxin may produce many of the health effects associated with particulate air pollution. We hypothesize that outdoor endotoxin concentrations correlate well with PM10 concentrations, and we will determine indoor/outdoor ratios for airborne endotoxin. These data may help determine the size range of particles most strongly associated with asthma and may suggest a role for environmental endotoxin exposures.

Supplemental Keywords:

RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Epidemiology, Risk Assessments, Allergens/Asthma, Biochemistry, Atmospheric Sciences, ambient air quality, asthma, particle size, particulates, cardiopulmonary responses, human health effects, morbidity, endotoxin, endotoxin concentration, asthma indices, air pollution, airway inflammation, environmental health effects, airborne pollutants, human exposure, particulate exposure, indoor air quality, mortality, indoor environment, asthma morbidity, indoor-outdoor relationships

Progress and Final Reports:

  • 1998
  • 1999
  • 2000
  • 2001
  • 2002
  • 2003
  • Final

  • Main Center Abstract and Reports:

    R825702    Environmental Lung Disease Center (National Jewish Medical and Research Center)

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R825702C001 SP-A and SP-D in Environmental Lung Disease
    R825702C003 Adaptation to Nitrogen Dioxide: Role of Altered Glycolytic Pathway Enzyme Expression and NF-κB-Dependent Cellular Defenses Against Apoptosis
    R825702C005 Inhalation of Particulate Matter Alters the Allergic Airway Response to Inhaled Allergen
    R825702C006 Particle-Induced Lung Inflammation and Extracellular EC-SOD
    R825702C007 Indoor-Outdoor Relationships of Airborne Particle Count and Endotoxin Concentrations
    R825702C008 The Role of Mitochondrial DNA Mutations in Oxidant-Mediated Lung Injury
    R825702C009 Immunopathogenesis of Hypersensitivity Pneumonitis in the Mouse
    R825702C010 Activation of Natural T Lymphocytes by Diesel Exhaust Particulates Leads to Their Production of Interleukin-4 and TH2 Lymphocyte Differentiation to Allergen
    R825702C011 Latex Antigen Levels During Powdered and Powderless Glove Use
    R825702C012 Adjuvant Effects of Ozone in a Model of Allergen-Induced Airway Inflammation and Hyperresponsiveness
    R825702C013 Acute Exposure to Particulate Air Pollution in Childhood Asthma
    R825702C014 Mechanisms of Ozone Toxicity to the Lung