Molecular Mechanisms of Pesticide-Induced Developmental Toxicity

EPA Grant Number: R826886C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R826886
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: University of Washington
Center Director: Faustman, Elaine
Title: Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
Investigators: Faustman, Elaine , Mirkes, Phillip
Current Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through December 31, 2003
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health


This study will evaluate three "windows of sensitivity" in children's neurodevelopment, including in utero midbrain development and postnatal development of the cerebellum and hippocampus. Susceptibility to neurodevelopmental impacts will be defined by time of development in which exposures occur, specific target neuro tissues impacted and kinetics of molecular and cellular processes in that tissue at the time of exposure. The effects of three classes of pesticides will be assessed in vitro for specific cell systems and followed in vivo for both molecular, cellular and neurodevelopmental effects. Information from these studies will go directly into biologically based dose-response models that will be developed by the Risk Characterization Facility Core. These models will be developed for use in quantitative risk assessments to replace default approaches with scientifically based risk evaluation methods.

Publications and Presentations:

Publications have been submitted on this subproject: View all 4 publications for this subprojectView all 87 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 4 journal articles for this subprojectView all 73 journal articles for this center

Supplemental Keywords:

children, health, pesticide, exposure, neurodevelopment., RFA, Health, Scientific Discipline, Toxics, Environmental Chemistry, Health Risk Assessment, pesticides, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Children's Health, genetic susceptability, health effects, pesticide exposure, sensitive populations, environmental risks, exposure, developmental toxicity, biological response, neurodevelopment, children, Human Health Risk Assessment, neurodevelopmental, neurotoxicity, human exposure, polychlorinated biphenyls, susceptibility, children's vulnerablity, assessment of exposure, growth and development, neurodevelopmental toxicity, environmental toxicant, exposure pathways, environmentally caused disease, environmental health hazard, growth & development, sensitivity, windows of sensitivity, developmental disorders, exposure assessment, neurological development

Progress and Final Reports:

  • 1999
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003
  • Final

  • Main Center Abstract and Reports:

    R826886    University of Washington

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R826886C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
    R826886C002 Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
    R826886C003 Community-Based Participatory Research Project
    R826886C004 Pesticide Exposure Pathways Research Project