The Research Strategy of ORD's Global Change Research Program outlines a ten-year plan and a major redirection of the Program towards an emphasis on assessing the consequences of global change and on conducting research to support such assessments. Assessments will be conducted on the impacts of global change on human health, water quality, air quality, and ecosystem health. These four assessment areas represent topics for which EPA has substantial expertise and where EPA can contribute to the national scale assessment called for in the Global Change Research Act. In addition, the emphasis of the research program is consistent with the mandate and goals of the U.S. Global Change Research Program (USGCRP). The research Strategy represents a blueprint for research and assessment activities focused on understanding the risks and opportunities presented by global change, the interdependent and interactive effects of multiple stresses (including climate change and climate variability, UV radiation, and land use change), the human dimensions of global change, and adaptation options. The long-term goal of the Global Change Program is to articulate, in terms that are meaningful for decision makers and other stakeholders, the consequences of global environmental change for human health, ecosystems, and social well-being in the U.S.