US EPA

EPA released the draft report,Toxicological Review for Carbon Tetrachloride(Interagency Science Discussion Draft), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Carbon tetrachloride has been used as a dry-cleaning agent, fabric-spotting fluid, solvent, reagent in chemical synthesis, fire extinguisher fluid, and grain fumigant, but its primary use was in chlorofluorocarbon (CFC) production. Production of this chemical peaked in the early 1970s; annual production has generally declined since the mid-1970s. The Consumer Product Safety Commission banned the use of carbon tetrachloride in consumer products in the 1970s. Decline in the use of carbon tetrachloride also accompanied EPA’s increased regulation of the use of CFCs in propellants, and the Montreal Protocol, which was implemented in the U.S. via Title VI of the Clean Air Act Amendments of 1990 and that called for a ban (with certain exemptions) on production and import of carbon tetrachloride.

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of carbon tetrachloride that will appear on the Integrated Risk Information System (IRIS) database.

This assessment has been loaded into the IRIS Web site and Database.

U.S. EPA. IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/005D, 2010.