IRIS Toxicological Review and Summary Documents for 1,1,1-Trichloroethane (External Review Draft)
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1,1,1-Trichloroethane has been used primarily as a solvent for adhesives, in metal degreasing, and in the manufacture of vinylidene chloride. This chemical was formerly used as a food and grain fumigant. 1,1,1-Trichloroethane is one of the compounds addressed by the Montreal Protocol, under which the production and consumption of potentially ozone-depleting substances in the stratosphere are to be phased out. The final phase-out date for 1,1,1-trichloroethane in developed countries was 1996 (with selected exceptions for existing stocks and essential uses) and in developing countries is 2015.
The assessment of 1,1,1-trichloroethane is one of the chemicals in a pilot to explore the inclusion of reference values for less-than-lifetime exposure and other health assessment procedures/features recommended in the Risk Assessment Forum’s 2002 report, A Review of the Reference Dose and Reference Concentration Processes.
|1987||IRIS assessment of 1,1,1-trichloroethane posted on the IRIS database. (RfD only)|
|1988||Carcinogenicity assessment for 1,1,1-trichloroethane added to the IRIS database. [Related link]|
|1991||RfD withdrawn from the IRIS database.|
|Feb 2007||EPA released the external review draft for public review and comment.|
|Apr 2007||EPA hosted an independent peer review panel workshop to discuss the draft report.|
|Sep 2007||EPA released the final Toxicological Review of 1,1,1-Trichloroethane: in support of the Integrated Risk Information System (IRIS).|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (187 pp, 2 MB, about PDF)