DERMAL ABSORPTION OF CONTAMINANTS FROM SEDIMENTS/SOILS
The purpose of this project is develop models for estimating dermal absorption of contaminants from sediments/soils.
This project began in November 2002. To date SPME lab protocols have been developed and tested on several chemicals.
The mechanisms by which contaminants are released from sediments/soils and absorbed into the skin are poorly understood. The project will first conduct invitro experiments to study the effects of particle layering and chemical saturation. Secondly, mechanistic models will be developed to estimate dermal absorption into the skin. The final Co-op report was recieved in May 2007. Citation: Kissel JC, Spalt EW, Shirai JH, Bunge AL "Dermal Absorption of Chemical Contaminants from Soil" (book Cjapter) in Dermal Absorption and Toxicity Assessment, 2nd ed. (Roberts, MS and KA Walters, eds). Marcel Dekker Inc., New York, 2007.