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The U.S. EPA has conducted an external peer review of the scientific basis supporting the health hazard and dose-response assessment for methyl ethyl ketone that will appear on the Agency's online data base, the Integrated Risk Information System (IRIS). Peer review is meant to ensure that science is used credibly and appropriately in derivation of this dose-response assessment. The draft Toxicological Review for Methyl Ethyl Ketone and draft IRIS Summary have undergone internal Agency review.


U.S. EPA. IRIS TOXICOLOGICAL REVIEW OF METHYL ETHYL KETONE [AND IRIS SUMMARY] (EXTERNAL REVIEW DRAFT). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, NCEA-S-1399, 2003.

Additional Information

EPA is hereby providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of methyl ethyl ketone. These documents are provided for public viewing during an external scientific peer review period. While EPA is not soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to May 9, 2003 will be considered in subsequent drafts.

Please direct any correspondence to: Susan Rieth, National Center for Environmental Assessment (8601D), U.S. EPA, 1200 Pennsylvania Ave., N.W., Washington, D.C. or to Also, please send a recordkeeping copy to: IRIS Submission Desk, c/o ASRC, Inc., 6301 Ivy Lane, Suite 301, Greenbelt, MD 20770 or email to

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.