Thyroid Follicular Cell Carcinogenesis: Mechanistic and Science Policy Considerations (Sab Review Draft)
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(1) thyroid follicular cell tumors may arise from long-term disturbances in thyroid-pituitary hormonal feedback under conditions of reduced circulating thyroid hormone and elevated thyroid stimulating hormone (TSH);
(2) the steps leading to these tumors are expected to show thresholds, such that the risks of tumor development are minimal when thyroid-pituitary homeostasis exists; and
(3) models that assume thresholds may be used to assess the risks of certain thyroid follicular cell tumors where there is evidence of thyroid-pituitary imbalance.
The policy set out in this report provides guidance on determining whether it is reasonable to presume that the observed thyroid follicular tumors are the result of thyroid-pituitary imbalance, and on selecting appropriate procedures to use in estimating the risks related to these tumors.