Assessment of the Mutagenic Potential of Carbon Disulfide, Carbon Tetrachloride, Dichloromethane, Ethylene Dichloride, and Methyl Bromide: A Comparative Analysis in Relation to Ethylene Dibromide
Notice - This site contains archived material(s)
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please use the contact us form if you need additional support.
The potential of the alternatives to reach whole mammal germcell DNA has not been studied. But DCM, EDC, and MB do cause heritable effects in Drosophila. CS2 and CCl4 have been predominately negative in mutagenicity tests. Additional studies are needed before a final judgment is reached with respect to their mutagenic potential, however. The mutagenic potencies of each agent were compared within and among various assay systems. Regarding the strength of mutagenicity, EDB is clearly a stronger mutagen than any of the proposed alternative fumigants. Differences in mutagenicity potency among the alternatives cannot be delineated because of limited data usually derived from different laboratories. When final judgments could not be reached because of gaps in current knowledge, recommendations were made on additional studies that could be conducted to better define the potential mutagenic risk.