Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons
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For the majority of PAHs classified as B2, probable human carcinogens, data are insufficient for calculation of an inhalation or drinking water unit risk. Benzo[a]pyrene (BAP) is the most completely studied of the PAHS, and data, while problematic, are sufficient for calculation of quantitative estimates of carcinogenic potency. Toxicity Equivalency Factors (TEF) have been used by U.S. EPA on an interim basis for risk assessment of chlorinated dibenzodioxins and dibenzofurans. Data for PAHs do not meet all criteria for use of TEF. This document presents a somewhat different approach to quantitative estimation for PAHs using weighted potential potencies. These estimates are recommended only for evaluation of risk from oral exposure and are proposed only for the assessment of potential carcinogenicity of PAHS.
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
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