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The Health and Environmental Effects Profile for Bromobenzenes was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA). Both published literature and information obtained from Agency program office files were evaluated as they pertained to potential human health, aquatic life and environmental effects of hazardous waste constituents. Quantitative estimates have been presented provided sufficient data are available. Existing data are insufficient to determine an Acceptable Daily Intake (ADI) or a carcinogenic potency factor for Bromobenzenes as a class. 1,4-Dibromobenzene, 1,2,4-Tribromobenzene and Hexabromobenzene have been determined to be systemic toxicants. An Acceptable Daily Intake (ADI), defined as the amount of a chemical to which humans can be exposed on a daily basis over an extended period of time (usually a lifetime) without suffering a deleterious effect, for 1,4-Dibromobenzene is .01 (mg/kg bw/day), for 1,2,4-Tribromobezene is .005 (mg/kg bw/day) and for Hexabromobenzene is .002 (mg/kg bw/day) for oral exposure.
U.S. EPA. Health and Environmental Effects Profile for Bromobenzenes. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/X-84/128 (NTIS PB88137757), 1984.