US EPA

The Health and Environmental Effects Profile for N,N-Dimethylformamide was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA) and to provide health-related limits for emergency actions under Section 101 of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA). Both published literature and information obtained from Agency program office files were evaluated as they pertained to potential human health aquatic life and environmental effects of hazardous waste constituents. Quantitative estimates have been presented provided sufficient data are available. N,N-Dimethylformamide has been determined to be a systemic toxicant. An Acceptable Daily Intake (ADI), defined as the amount of a chemical to which humans can be exposed on a daily basis over an extended period of time (usually a lifetime) without suffering a deleterious effect, for N,N-dimethylformamide is 0.096 mg/kg/day for oral exposure. The Reportable Quantity (RQ) value for N,N-dimethylformamide is 100.

U.S. EPA. Health And Environmental Effects Profile for N,N-Dimethylformamide. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/X-86/141 (NTIS PB88219662), 1986.