Notice - This site contains archived material(s)
Archived files are provided for reference purposes only. The file
was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived
files may contact the NCEA Webmaster for assistance. Please use the contact us form if you need additional support.
The health assessment document on polychlorinated dibenzo-p-dioxins discusses multimedia environmental issues pertaining to the most toxic chlorinated dioxins, namely, 2,3,7,8-tetrachloro-; 1,2,3,7,8-pentachloro-; 1,2,3,6,7,8-hexachloro-; and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins. Scientifically valid data essential for human health risk assessment purposes from an extensive literature search have been compiled and discussed critically. Discussions are based on physiochemical properties and analytical methodologies; stability and degradation; production, use, synthesis; environmental resources and environmental levels; environmental ffate and transport; degradation; bioaccumulation and bioconcentration factors; ecological effects; various aspects of toxic effects from acute, subchronic and chronic exposures in experimental animals and humans; pharmacokinetics and mechanism of toxic effects; teratogenicity and reproductive effects; mutagenicity and carcinogenecity. Based on this review, critical studies have been identified and utilized for estimating the unit risk.
U.S. EPA. Health Assessment Document for Polychlorinated Dibenzo-P-Dioxins (1985). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-84/014F (NTIS PB86122546), 1985.