US EPA

The Health and Environmental Effects Profile for 2-methoxyethanol was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA) and to provide health-related limits for emergency actions under Section 101 of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA). Both published literature and information obtained from Agency program office files were evaluated as they pertained to potential human health, aquatic life and environmental effects of hazardous waste constituents. Quantitative estimates have been presented provided sufficient data are available. 2-Methoxyethanol has been determined to be a systemic toxicant. A Reference Dose (RfD), defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of the daily exposure to the human population (including sensitive subgroups) that is likely to be without appreciable risk of deleterious effect during a lifetime, for 2-methoxyethanol is 0.001 mg/kg/day for inhalation exposure. The Reportable Quantity (RQ) value of 1, 10, 100, 1000 or 5000 pounds is used to determine the quantity of a hazardous substance for which notification is required in the event of a release as specified by CERCLA based on chronic toxicity. The RQ value for 2-methoxyethanol is 100.

U.S. EPA. Health And Environmental Effects Profile for 2-Methoxyethanol. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/X-87/025 (NTIS PB89119531).