Notice - This site contains archived material(s)
Archived files are provided for reference purposes only. The file
was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived
files may contact the NCEA Webmaster for assistance. Please use the contact us form if you need additional support.
The scientific debate over the potential carcinogenicity of tetrachloroethylene (perchloroethylene, perc, PCE) spans several years. his document reviews the issues considered by the EPA's Science Advisory Board (SAB) during its review of the Draft Addendum to the Health Assessment Document for Tetrachloroethylene (1986) and discusses relevant research data published between 1986 and early 1991. he topics include three tumor end points observed in rodents: ) hepatocellular carcinoma in male and female mice, 2) renal tubule neoplasia in male rats, and 3) mononuclear cell leukemia in male and female rats, and data on metabolism, mutagenicity, peroxisome proliferation, and alpha-2u-globulin. PA's recommended weight-of-evidence classification of perc is B2, probable human carcinogen. he SAB reviewed the February 1991 draft of this report at a public meeting and found the report to be well written and of high scientific quality, although the SAB recommended placing perc on a continuum between Group B2 and Group C weight-of-evidence categories.
Parker, J. RESPONSE TO ISSUES AND DATA SUBMISSIONS ON THE CARCINOGENICITY OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/6-91/002F (NTIS PB95221958).