The EPA Adverse Outcome Pathway Database (Aop-Db) Application User Manual
The manual covers basic search functionality and description of the content and format of the data accessible through the AOP-DB. Adverse outcome pathways (AOPs) are a conceptual framework intended to enhance the utility of pathway-based data for use in risk-based regulatory decision support. The framework is designed to aid the organization and evaluation of predictive relationships between measures of the initiation or progression of a stressor-induced perturbation and adverse outcomes that occur at a level of biological organization considered relevant to regulatory decision-making.
The Agency has committed to research that advances predictive applications of the AOP framework under the CSS Research Program. The research provides a critical scientific foundation for 21st century approaches to toxicity testing which seek to make increased use of lower cost, higher throughput and/or higher content, in vitro, in silico, and/or short-term in vivo testing for single chemical hazard assessment. It also provides the scientific framework to assess the human/ecological relevance of pathway-based effects across different model systems and address the challenges posed by exposure to multiple stressors in the environment.
Central to this effort is the development of an AOP database (AOP-DB) to house, organize, profile and disseminate the AOP information. Potential users of the AOP-DB are any researchers (e.g. International or National, government, academic, and industry) interested in the study of AOPs, such as federal and program partners, OECD (Organization for Economic Co-operation and Development) partners, or AOPWiki users that may like organized biological information on specific AOPs for basic research or regulatory purposes.
The Agency has committed to research that advances predictive applications of the AOP framework under the CSS Research Program. The research provides a critical scientific foundation for 21st century approaches to toxicity testing which seek to make increased use of lower cost, higher throughput and/or higher content, in vitro, in silico, and/or short-term in vivo testing for single chemical hazard assessment. It also provides the scientific framework to assess the human/ecological relevance of pathway-based effects across different model systems and address the challenges posed by exposure to multiple stressors in the environment.
Central to this effort is the development of an AOP database (AOP-DB) to house, organize, profile and disseminate the AOP information. Potential users of the AOP-DB are any researchers (e.g. International or National, government, academic, and industry) interested in the study of AOPs, such as federal and program partners, OECD (Organization for Economic Co-operation and Development) partners, or AOPWiki users that may like organized biological information on specific AOPs for basic research or regulatory purposes.
Impact/Purpose
This user manual is used for training and guidance in the use of the EPA Adverse Outcome Pathway Database (AOP-DB).
Citation
U.S. EPA. The EPA Adverse Outcome Pathway Database (Aop-Db) Application User Manual. U.S. EPA Office of Research and Development, Washington, DC, EPA/600/R-21/136, 2021.
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.