Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials, 2019)

Notice

EPA announces the availability of the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) for a 45-day public comment period. EPA also announces a public science meeting (via webinar) scheduled for April 24, 2019.

Abstract

In March 2019, EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

The IRIS Program posts assessment protocols and protocol updates publicly on a chemical’s HERO project page, the IRIS website, and in systematic review repositories such as Zenodo (https://zenodo.org/record/2654896#.XMsScOhKjcs).

Impact/Purpose

This document presents a draft assessment plan for hexavalent chromium that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in the spring of 2019 and that will define the scope and approach of the IRIS assessment of this chemical.

Status

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.

Citation

U.S. EPA. Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials, 2019). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/155, 2019.

History/Chronology

Date Description
01-Apr 2014EPA released preliminary meeting materials for chromium (VI), part 1, in preparation for the June 2014 Bimonthly Public Science Meeting.
02-Jun 2014EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 1.
03-Aug 2014EPA released preliminary meeting materials for chromium (VI), part 2, in preparation for the October 2014 Bimonthly Public Science Meeting.
04-Oct 2014EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 2.
05-Mar 2019EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Mar 15, 2019]
06-Apr 2019EPA announced that they will host a public science meeting on April 24, 2019 (by webinar) to discuss the draft document.

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2014-0313