US EPA

A series of napthalene diols, quinones, and related compounds were examined for their ability to inhibit mixed-function oxidase activities in liver microsomes obtained from rats which had been pretreated with 3-methylcholanthrene (3-MC) or phenobarbital (PB). Using benzo(a)pyrene monooxygenase as a measure of mixed-function oxidase activity, it was found that phenanthrene-9,10-quinone was the most active compound tested with a K1=0.79 uM.

Nesnow, S., H. Bergman, H. Garland, AND M. Morris. INHIBITION OF MICROSOMAL METABOLISM AND CHEMICAL ONCOGENESIS IN CULTURE BY NAPHTHALENE QUINONES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-79/149 (NTIS PB83145284).

Pub. in Jnl. of Environmental Pathology and Toxicology 4, p17-30 1980.