Summary Report: State-of-the-Science Workshop on Chemically-Induced Mouse Lung Tumors: Applications to Human Health Assessments
Notice
EPA announces the availability of the final report, SUMMARY REPORT: State-of-the-Science Workshop on Chemically-Induced Mouse Lung Tumors: Applications to Human Health Assessments. The report is a brief summary of the proceedings of the workshop which included four separate sessions examining individual topic areas in detail, beginning with and continually referring back to the human relevance of data from animal and in vitro studies.Abstract
The EPA hosted a two-day, state-of-the-science workshop which covered a broad range of evidence from human, animal, and in vitro studies with a focus on specific chemicals (ethylbenzene, naphthalene, and styrene) that cause lung tumors in mice and are implicated in a proposed species-specific mode of action (MOA) based on metabolic and physiological susceptibility. The workshop was sponsored and organized by EPA with input from (1) a volunteer committee of outside experts (including representatives from academic institutions, State agencies, other Federal organizations, NGOs, and industry), and (2) an internal working group of experts from EPA and other Federal partners.
Impact/Purpose
The primary goal of the MLTW was to help inform the development of IRIS assessment documents for the three key chemicals: ethylbenzene, naphthalene, and styrene.
Citation
U.S. EPA. Summary Report: State-of-the-Science Workshop on Chemically-Induced Mouse Lung Tumors: Applications to Human Health Assessments. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-14/002, 2014.
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.