IRIS Toxicological Review of Benzo[a]pyrene (Interagency Science Consultation Draft)
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Abstract
BaP is found in the environment primarily as a result of the incomplete burning of materials that contain carbon. It is one of a group of compounds called polycyclic aromatic hydrocarbons (PAHs). BaP (along with other PAHs) is released into the atmosphere as a component of smoke from forest fires, industrial processes, vehicle exhaust, cigarettes, and through the burning of fuel (such as wood, coal, and petroleum products). People can be exposed to BaP by breathing particles that contain carbon (e.g. soot, diesel particles) to which PAHs have adhered. People can also be exposed to BaP by eating foods grown in areas with air or soil contaminated with BaP or by eating certain food products, such as charred meats, where BaP is formed during the cooking process. People can also be exposed to BaP through the skin after coming into contact with soils or materials that contain soot, tar, or crude petroleum products or by using certain pharmaceutical products containing coal tars, such as those used to treat the skin conditions eczema and psoriasis.
This draft is a reassessment of an IRIS assessment posted in 1987 and includes an oral reference dose, inhalation reference concentration, oral slope factor, inhalation unit risk, and dermal slope factor. It is the first IRIS assessment to propose a dermal slope factor.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Jun 2011 | EPA initiated the interagency science consultation on the draft Toxicological Review of Benzo[a]pyrene. |
Aug 2013 | EPA released the external review draft for public review and comment. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Benzo[a]pyrene (Interagency Consultation Draft) -- Jun 2011 (PDF) (419 pp, 3 MB, about PDF)
- Charge to Reviewers -- Jun 2011 (PDF) (4 pp, 29 KB, about PDF)
- 1. CDC ATSDR Comments on the BaP IASC (PDF) (2 pp, 25 KB, about PDF)
- 2. CDC NIOSH Comments on the BaP IASC (PDF) (4 pp, 40 KB, about PDF)
- 3. CEQ Comments on the BaP IASC (PDF) (1 pp, 32 KB, about PDF)
- 4. DOD DUSC (I&E) Comments on the BaP IASC (PDF) (1 pp, 271 KB, about PDF)
- 5. DOD DUSC (I&E) Follow-up Comments on the BaP IASC (PDF) (3 pp, 34 KB, about PDF)
- 6. NASA Comments on the BaP IASC (PDF) (3 pp, 30 KB, about PDF)
- 7. NIEHS Comments on the BaP IASC (PDF) (1 pp, 29 KB, about PDF)
- 8. OMB Comments on the BaP IASC (PDF) (9 pp, 75 KB, about PDF)
- IRIS Toxicological Review of Benzo[a]pyrene (Revised Interagency Consultation Draft) -- Jun 2012 (PDF) (179 pp, 3 MB, about PDF)
- IRIS Supplemental Information for the Toxicological Review of Benzo[a]pyrene (Interagency Consultation Draft) -- Jun 2012 (PDF) (251 pp, 3 MB, about PDF)
- Charge to Reviewers - Jun 2012 (PDF) (5 pp, 331 KB, about PDF)
- 1. NASA EMD Comments on the BaP Revised IASC (PDF) (1 pp, 151 KB, about PDF)
- 2. CDC ATSDR Comments on the BaP Revised IASC (PDF) (2 pp, 131 KB, about PDF)
- 3. CDC NIOSH Comments on the BaP Revised IASC (PDF) (2 pp, 175 KB, about PDF)
- 4. CEQ Comments on the BaP Revised IASC (PDF) (1 pp, 84 KB, about PDF)
- 5. DOD DUSC (I&E) Comments on the BaP Revised IASC (PDF) (23 pp, 235 KB, about PDF)
- EPA’s Response to Major Interagency Comments (PDF) (9 pp, 309 KB, about PDF)