IRIS Toxicological Review of Hexachloroethane (2011 Final)

EPA is announcing the release of the final report Toxicological Review of Hexachloroethane: in support of the Integrated Risk Information System (IRIS). The updated Summary for Acrylamide and accompanying Quickview have also been added to the IRIS database.

The IRIS Toxicological Review of hexachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hexachloroethane. Hexachloroethane (C2Cl6) is a colorless, nonflammable, crystalline solid primarily used in the military for pyrotechnic devices. Hexachloroethane has been used as a polymer additive, moth repellant, plasticizer for cellulose esters, insecticide solvent, and for refining aluminum alloys. Hexachloroethane is not commercially distributed in the United States. Exposure to hexachloroethane is primarily occupational, via inhalation and dermal exposure during hexachloroethane manufacturing and metal refining. Exposure may occur in military or civilian personnel working with pyrotechnic devices containing hexachloroethane and via ingestion of contaminated drinking water or fish. Hexachloroethane was identified in Superfund sites.

This assessment contains the derivation of a chronic oral reference dose (RfD), chronic inhalation reference concentration (RfC), and an oral cancer slope factor.


U.S. EPA. IRIS Toxicological Review of Hexachloroethane (2011 Final). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/007F, 2011.


Sep 1987The oral RfD and cancer assessment for hexachloroethane was posted to the IRIS database.
Apr 2010EPA initiated the interagency science consultation on the draft Toxicological Review of Hexachloroethane.
May 2010EPA released the External Review Draft for public review and comment. EPA also announced a public listening session to be held on June 16, 2010. [Federal Register May 13, 2010]
Aug 2010EPA announced an independent peer review meeting to be held in Arlington, VA on September 21, 2010. [Federal Register Aug 2, 2010]
Dec 2010EPA releases the comments from the public comment period and external review workshop.
Jul 2011EPA released the final toxicological review report, summary document and quickview web page and posted these to the IRIS database.