IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft)
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Abstract
The draft Toxicological Review of hexachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hexachloroethane. Hexachloroethane (C2Cl6) is a colorless, nonflammable, crystalline solid primarily used in the military for pyrotechnic devices. Hexachloroethane has been used as a polymer additive, moth repellant, plasticizer for cellulose esters, insecticide solvent, and for refining aluminum alloys. Hexachloroethane is not commercially distributed in the United States. Exposure to hexachloroethane is primarily occupational, via inhalation and dermal exposure during hexachloroethane manufacturing and metal refining. Exposure may occur in military or civilian personnel working with pyrotechnic devices containing hexachloroethane and via ingestion of contaminated drinking water or fish. Hexachloroethane was identified in Superfund sites.
Impact/Purpose
Status
Citation
History/Chronology
| Date | Description |
|---|---|
| Apr 2010 | EPA hosted an interagency science consultation on the draft Toxicological Review of Hexachloroethane. |
| May 2010 | EPA released the external review draft for public comment. EPA also announced a public listening session on June 16, 2010. [Federal Register May 13, 2010] |
| Aug 2010 | EPA announced the external peer review meeting to be held on September 21, 2010. [Federal Register Aug 2, 2010] |
| Dec 2010 | EPA released the comments from the external review workshop. |
| May 2011 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Hexachloroethane. |
| Sep 2011 | EPA released the final toxicological review and IRIS Summary for HCE and the interagency review draft with interagency review comments. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft) (PDF) (225 pp, 1 MB, about PDF)
- draft Hexachloroethane Summary (Interagency Science Discussion Draft) (PDF) (28 pp, 200 KB, about PDF)
- EPA's Response & Interagency Science Discussion Comments (PDF) (24 pp, 228 KB, about PDF)
- 1. CDC ATSDR HCE IASD Comments (PDF) (3 pp, 59 KB, about PDF)
- 2. DOD HCE IASD Comments (PDF) (6 pp, 105 KB, about PDF)
- 3. NIEHS HCE IASD Comments (PDF) (1 pp, 12 KB, about PDF)
- 4. OMB HCE IASD Comments (PDF) (7 pp, 105 KB, about PDF)