IRIS Toxicological Review and Summary Documents For Tetrachloroethylene

The known toxic effects of perchloroethylene will be summarized, with citations from current scientific literature. The critical effects will be identified, and from this the RfD and RfC and cancer unit risk factors will be derived. The RfD and RfC are reference doses and air concentrations that are generally regarded as safe under conditions of chronic exposure. The cancer unit risks in air and drinking water are the estimated lifetime cancer risks expected to occur from a lifetime exposure to a concentration of 1 microgram per cubic meter in the air and to a drinking water concentration of 1 microgram per liter. This summary document will be peer reviewed within the Agency and by experts outside the Agency according to the standard IRIS procedures. For up-to-date project schedules see IRIS Track at


The U.S. EPA is conducting a new health assessment of tetrachloroethylene that will appear on the Agency's online database, the Integrated Risk Information System (IRIS). IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment process, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risks associated with environmental contaminants.


U.S. EPA. IRIS Toxicological Review and Summary Documents For Tetrachloroethylene. U.S. Environmental Protection Agency, Washington, DC.