IRIS Toxicological Review of Phosgene (Final Report)
EPA announced the release of the final report, Toxicological Review of Phosgene: in support of the Integrated Risk Information System (IRIS). The updated Summary for Phosgene and accompanying toxicological review have been added to the IRIS Database.
The Toxicological Review of Phosgene discusses the potential human health effects of chronic exposure to phosgene. While the report discusses both cancer and noncancer endpoints, the focus of the document is on noncancer chronic effects due to a lack of adequate information about cancer exposure hazards. Some discussion of acute exposure health hazards is also contained in the document. Phosgene exposure may occur in the workplace and environment as a result of chemical processes. Phosgene is used primarily in the manufacture of polyurethane. It is also used in the polycarbonate industry and in the manufacture of certain pesticides, dyes, perfumes, and pharmaceuticals. A 1990 summary file on phosgene included in EPA's Integrated Risk Information System (IRIS) concluded that the available data were inadequate for derivation of a reference concentration (RfC) for potential noncancer effects resulting from inhalation exposure, a reference dose (RfD) for potential noncancer effects resulting from oral exposure, or an estimate of carcinogenic risk to humans. While this updated document includes a proposed RfC, it still concludes that there is inadequate information for the derivation of an RfD or cancer risk estimates.
The Toxicological Review of Phosgene discusses the potential human health effects of chronic exposure to phosgene. While the report discusses both cancer and noncancer endpoints, the focus of the document is on noncancer chronic effects due to a lack of adequate information about cancer exposure hazards. Some discussion of acute exposure health hazards is also contained in the document. Phosgene exposure may occur in the workplace and environment as a result of chemical processes. Phosgene is used primarily in the manufacture of polyurethane. It is also used in the polycarbonate industry and in the manufacture of certain pesticides, dyes, perfumes, and pharmaceuticals. A 1990 summary file on phosgene included in EPA's Integrated Risk Information System (IRIS) concluded that the available data were inadequate for derivation of a reference concentration (RfC) for potential noncancer effects resulting from inhalation exposure, a reference dose (RfD) for potential noncancer effects resulting from oral exposure, or an estimate of carcinogenic risk to humans. While this updated document includes a proposed RfC, it still concludes that there is inadequate information for the derivation of an RfD or cancer risk estimates.
Impact/Purpose
Phosgene is used primarily in the manufacture of polyurethane. It is also used in the polycarbonate industry and in the manufacture of certain pesticides, dyes, perfumes, and pharmaceuticals.
Citation
U.S. EPA. IRIS Toxicological Review of Phosgene (Final Report). U.S. Environmental Protection Agency, Washington, DC, 2005.
History/Chronology
| Date | Description |
|---|---|
| Mar 2004 | EPA released the draft report for external peer review. |
| Jan 2006 | EPA released the final tox report and summary document and posted these to the IRIS database. |
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
- IRIS Toxicological Review and Summary Documents for Phosgene (2005 Final) (PDF) (102 pp, 626 KB, about PDF)
- IRIS Summary for Phosgene (PDF) (22 pp, 166 KB, about PDF)