IRIS Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft)
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Abstract
The draft Toxicological Review of Trichloroethylene (TCE) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to TCE. TCE is a chlorinated solvent that has been widely used as a metal degreaser, as a chemical intermediate and extractant, and as a component of some consumer products. TCE is designated as a Hazardous Air Pollutant, is a common groundwater contaminant, and has been found at more than 1,500 hazardous waste sites. TCE enters the atmosphere from vapor degreasing operations or volatilization from contaminated soils, surface waters via direct discharges, and groundwater through leaching from disposal operations and hazardous waste sites. In addition, TCE can be released to indoor air from the use of TCE-containing consumer products, volatilization from water supplies, and vapor intrusion through walls and floors from contaminated soil and groundwater.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Aug 2001 | EPA released an External review draft Trichloroethylene Health Risk Assessment: Synthesis and Characterization for public review and comment. |
Dec 2002 | EPA's Science Advisory Board released an independent peer review report Review of Draft Trichloroethylene Health Risk Assessment: Synthesis and Characterization: An EPA Science Advisory Board Report (PDF, 83 pp, 376 KB, about PDF). |
Feb 2004 | EPA hosted a Symposium on New Scientific Research Related to the Health Effects of Trichloroethylene held in Washington, DC. |
Sep 2004 | The National Academy of Science (NAS) initiated the project “Assessing the Human Health Risks of Trichloroethylene : Key Scientific Issues” under sponsorship of EPA and other federal agencies. |
Feb 2005 | EPA submitted four TCE issue papers on key scientific issues to the NAS. |
July 2006 | The National Academy of Science (NAS) released the report Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues Consultation. |
Sep 2009 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Trichloroethylene. |
Oct 2009 | EPA Science Advisory Board (SAB) releases Federal Register Notice requesting nominations of experts for the SAB TCE Review Panel. |
Nov 2009 | EPA releases the External Reviewer Draft for public comment and review. |
Additional Information
Instructions for accessing supplementary files to Appendices A, F, and G.
(1) Download the ".zip" file.
(2) "Extract" files using Microsoft Windows or equivalent decompression software, creating a folder named "Appendix.linked.files"
(3) Move the folder "Appendix.linked.files" to the same directory where the PDF file for Appendix A, F, or G is located.
(4) Open the PDF file for Appendix A, F, or G using Adobe Acrobat Reader. To open the supplementary files, click on the appropriate links.
- Toxicological Review of Trichloroethylene (Interagency Science Consultation Draft) (PDF) (1255 pp, 5 MB, about PDF)
- Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF) (4 pp, 34 KB, about PDF)
- Appendix A: PBPK Modeling of TCE and Metabolites – Detailed Methods and Results (PDF) (108 pp, 1 MB, about PDF)
- Appendix B: Systematic Review of Epidemiologic Studies on Cancer and Trichloroethylene (TCE) Exposure (PDF) (348 pp, 2 MB, about PDF)
- Appendix C: Meta-analysis of Cancer Results from Epidemiological Studies (PDF) (71 pp, 410 KB, about PDF)
- Appendix D: Neurological Effects of Trichloroethylene (PDF) (136 pp, 937 KB, about PDF)
- Appendix E: ANALYSIS OF LIVER AND CO-EXPOSURE ISSUES FOR THE TCE TOXICOLOGICAL REVIEW (PDF) (396 pp, 2 MB, about PDF)
- Appendix F: TCE Non-Cancer Dose-Response Analyses (PDF) (40 pp, 419 KB, about PDF)
- Appendix G: TCE Cancer Dose-Response Analyses with Rodent Cancer Bioassay Data (PDF) (41 pp, 894 KB, about PDF)
- Appendix H: Lifetable Analysis/Equations Used for Weighted Linear Regression of Results from Charbotel et al. (2006) (PDF) (4 pp, 173 KB, about PDF)
- Appendix Linked Files (zip, 90 MB) (ZIP) (879 MB, about ZIP)
Related Link(s)
- USDA Comments on the review of Trichloroethylene (PDF) (2 pp, 27 KB, about PDF)
- OMB Comments on the review of Trichloroethylene (PDF) (2 pp, 38 KB, about PDF)
- ATSDR Comments on the review of Trichloroethylene (PDF) (1 pp, 13 KB, about PDF)
- NASA Comments on the review of Trichloroethylene (PDF) (8 pp, 131 KB, about PDF)
- DoD Comments on the review of Trichloroethylene (PDF) (72 pp, 436 KB, about PDF)
- DoD Comments on the Charge Questions (PDF) (4 pp, 36 KB, about PDF)