IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Sep 1988 | EPA posted the trans-1,2-dichloroethylene assessment (RfD only). |
Dec 1990 | EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only). |
Aug 2009 | EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of cis-and trans-1,2-Dichloroethylene . These comments are provided on this web site. |
Sep 2009 | EPA released an External Review Draft of the assessment for public review and comment. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of cis- and trans-1,2-dichloroethylene (Interagency Science Consultation Draft) (PDF) (152 pp, 822 KB, about PDF)
- Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF) (3 pp, 16 KB, about PDF)
- 1. Department of Defense Comments on the Toxicological Review of cis- and trans-1,2-dichloroethylene (Interagency Science Consultation Draft) (PDF) (3 pp, 29 KB, about PDF)
- 2. Department of Defense Comments on the draft Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF) (1 pp, 19 KB, about PDF)