IRIS TOXICOLOGICAL REVIEW OF BORON AND COMPOUNDS (EXTERNAL REVIEW DRAFT 2001)
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The IRIS Toxicological Review for Boron and IRIS Summary Sheets have previously gone through an internal and external review. However certain sections of the Toxicological Review have been revised since these peer reviews took place. Revisions were made to include new pharmacokinetic data received from U. S. Borax after the internal and external reviews took place. The revised sections of the Toxicological Review and RfD Summary sheet were changed to include new data and have now gone through an Internal EPA Review. Internal reviewer comments have been addressed and these sections now need External Peer Review. This review would include an analysis of Section 3.4, 3.4.1, 3.4.2, 3.5 and Section 5.1.3. of the Toxicological Review and the RfD Summary Sheet which include use of new toxicokinetic data to derive a data derived uncertainty factor. This review is needed before the Toxicological Review and IRIS Summary sheets for Boron are forwarded to the EPA's Consensus Review Process for final approval and adoption by the EPA. These hazard and dose-response assessments will then appear on IRIS and become available as agency consensus health effect information.
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