IRIS Toxicological Review of Hexavalent Chromium (2010 Interagency Science Consultation Draft)
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
The draft Toxicological Review of Hexavalent Chromium provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hexavalent chromium via ingestion.
Chromium is a naturally occuring element in the earth's crust. The three main forms of chromium found in the environment are chromium (0), chromium (III), and chromium (VI), also known as hexavalent chromium. Chromium is widely used in manufacturing processes, and it can be found in many consumer products such as wood treated with copper dichromate, leather tanned with chromic sulfate, and stainless steel cookware. Chromium is released to the environment from natural and anthropogenic sources, with the largest releases occurring from industrial sources. The general population may be exposed to chromium by inhaling ambient air, ingesting food, and drinking water containing chromium. Dermal exposure of the general public to chromium can occur from skin contact with certain consumer products or soils that contain chromium.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Sep 1998 | The oral RfD for hexavalent chromium was posted to the IRIS database. The inhalation RfC for hexavalent chromium and the carcinogenicity assessment for hexavalent chromium were also posted to the IRIS database. |
May 2010 | EPA initiated the interagency science consultation on the draft Toxicological Review of Hexavalent Chromium. |
Sep 2010 | EPA released the external review draft for public review and comment. Additionally, EPA released the draft toxicological review and federal agency comments from the Interagency Science consultation. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Hexavalent Chromium (Interagency Science Consultation Draft) (PDF) (260 pp, 2 MB, about PDF)
- Charge to External Reviewers (Interagency Science Consultation Draft) (PDF) (2 pp, 21 KB, about PDF)
- ATSDR Comments of the Review of Hexavalent Chromium (PDF) (2 pp, 23 KB, about PDF)
- DOD Comments of the Review of Hexavalent Chromium (PDF) (15 pp, 137 KB, about PDF)
- DOD Comments of the charge questions for the Review of Hexavalent Chromium (PDF) (2 pp, 22 KB, about PDF)
- NTP Comments of the Review of Hexavalent Chromium (PDF) (2 pp, 407 KB, about PDF)
- OMB Comments of the Review of Hexavalent Chromium (PDF) (4 pp, 33 KB, about PDF)